B-hPOSTN mice

C57BL/6-Postntm1(POSTN)Bcgen/Bcgen • 111227

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B-hPOSTN mice

Product nameB-hPOSTN mice
Catalog number111227
Strain nameC57BL/6-Postntm1(POSTN)Bcgen/Bcgen
Strain backgroundC57BL/6
AliasesPOSTN: PN; OSF2; OSF-2; PDLPOSTN
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  • Targeting strategy
  • Phenotypic analysis

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Targeting strategy

Gene targeting strategy for B-hPOSTN mice. The exon 2-24 of mouse Postn gene that encodes the full-length protein was replaced by human POSTN exon 1-23 in B-hPOSTN mice.

Protein expression analysis
Strain specific POSTN expression analysis in homozygous B-hPOSTN mice by ELISA. Serum was isolated from wild-type C57BL/6 mice (+/+) and homozygous B-hPOSTN mice (H/H), serum was collected and analyzed by ELISA with species-specific POSTN ELISA kit. Mouse POSTN was detectable in wild-type mice (A). Human POSTN was exclusively detectable in homozygous B-hPOSTN mice (B).