B-NDG hB2M/HLA-A3.1 mice

NOD.CB17-PrkdcscidIl2rgtm1BcgenB2mtm1(B2M/HLA-A3.1)Bcgen/Bcgen • 112450

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B-NDG hB2M/HLA-A24.2 mice plus
B-NDG hB2M/HLA-A3.1 mice plus

B-NDG hB2M/HLA-A3.1 mice

Product nameB-NDG hB2M/HLA-A3.1 mice
Catalog number112450
Strain nameNOD.CB17-PrkdcscidIl2rgtm1BcgenB2mtm1(B2M/HLA-A3.1)Bcgen/Bcgen
Strain backgroundB-NDG
AliasesB2m: Ly-m11, beta2-m, beta2m; HLA-A: HLAA
ApplicationTo verify the efficacy of HLA-A3.1 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
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  • Phenotypic analysis
Protein expression analysis
B2M and HLA-A3.1 expression analysis in homozygous B-NDG hB2M/HLA-A3.1 mice by flow cytometry. Splenocytes were collected from B-NDG mice (+/+) and homozygous B-NDG hB2M/HLA-A3.1 mice (H/H), and analyzed by flow cytometry with strain specific antibodies. Mouse B2M was detectable in B-NDG mice but not in B-NDG hB2M/HLA-A3.1 mice. Human B2M and HLA-A3 were exclusively detectable in homozygous B-NDG hB2M/HLA-A3.1 mice but not in B-NDG mice.