C57BL/6-Gfaptm1(icre)Bcgen/Bcgen • 110144
| Product name | B-Gfap-iCre mice |
|---|---|
| Catalog number | 110144 |
| Strain name | C57BL/6-Gfaptm1(icre)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| Official symbol | Gfap (glialfibrillary acidic protein) |
| Chromosome | 11 |
| Application | This Gfap-iCre model is an efficient tool to study various gene functions when crossed with mice with different loxP site-flanked genes of interest, especially in studies of astrocytes cells related signaling. |
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Description
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene editing strategy
Phenotype analysis
In situ hybridization in hippocampal CA1 area to confirm µR selective
deletion from µRGFAP-/- mice with probes of µR mRNA (red),
GAD2/ GFAP/vGlut1 mRNA (green), and DAPI nucleus staining (blue).
