C57BL/6-Ctla4tm1(CTLA4)Bcgen Cd137tm1(CD137)Bcgen/Bcgen • 120539
| Product name | B-hCTLA4/h4-1BB mice |
|---|---|
| Catalog number | 120539 |
| Strain name | C57BL/6-Ctla4tm1(CTLA4)Bcgen Cd137tm1(CD137)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| NCBI gene ID | 12477,21942 |
| Aliases | CTLA4 (Cytotoxic T-lymphocyte-associated protein 4,CD152)TNFRSF9 (Tumor necrosis factor receptor superfamily, member 9) |
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Protein expression analysis
Strain specific CTLA4 and 4-1BB expression analysis in homozygous B-hCTLA4/h4-1BB mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCTLA4/h4-1BB (H/H) mice stimulated with anti-CD3ε in vivo and analyzed by flow cytometry using species-specific anti-hCTLA4 and anti-h4-1BB antibodies. Mouse CTLA4 and 4-1BB were detectable in WT mice but not in homozygous B-hCTLA4/h4-1BB mice. Human CTLA4 and 4-1BB were exclusively detectable in homozygous B-hCTLA4/h4-1BB mice but not in WT mice.
