C57BL/6-Ctla4tm1(CTLA4)Bcgen Cd137tm1(CD137)Bcgen/Bcgen • 120539
| Product name | B-hCTLA4/h4-1BB mice |
|---|---|
| Catalog number | 120539 |
| Strain name | C57BL/6-Ctla4tm1(CTLA4)Bcgen Cd137tm1(CD137)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| NCBI gene ID | 3604,1493 (Human) |
| Aliases | 4-1BB, CD137, CDw137, ILA; ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12 |
Protein expression analysis
Strain specific CTLA4 and 4-1BB expression analysis in homozygous B-hCTLA4/h4-1BB mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCTLA4/h4-1BB (H/H) mice stimulated with anti-CD3ε in vivo and analyzed by flow cytometry using species-specific anti-hCTLA4 and anti-h4-1BB antibodies. Mouse CTLA4 and 4-1BB were detectable in WT mice but not in homozygous B-hCTLA4/h4-1BB mice. Human CTLA4 and 4-1BB were exclusively detectable in homozygous B-hCTLA4/h4-1BB mice but not in WT mice.
