C57BL/6-Ctla4tm1(CTLA4)Bcgen Lag3tm1(LAG3)Bcgen/Bcgen • 120529
| Product name | B-hCTLA4/hLAG3 mice |
|---|---|
| Catalog number | 120529 |
| Strain name | C57BL/6-Ctla4tm1(CTLA4)Bcgen Lag3tm1(LAG3)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| NCBI gene ID | 12477,16768 |
| Aliases | CTLA4 (Cytotoxic T-lymphocyte-associated protein 4,CD152);LAG3 (lymphocyte-activation gene 3) |
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Protein expression analysis
Strain specific CTLA4 and LAG3 expression analysis in homozygous B-hCTLA4/hLAG3 mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCTLA4/hLAG3 (H/H) mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-CTLA4 and anti-LAG3 antibody. Mouse CTLA4 was detectable in WT mice, mouse LAG3 was detectable in homozygous B-hCTLA4/hLAG3 and WT mice due to the anti-mouse LAG3 antibody cross-reacts with human LAG3. Human CTLA4 and LAG3 were exclusively detectable in homozygous B-hCTLA4/hLAG3 but not WT mice.
