B-hCXCL7/hCXCL4 mice

C57BL/6N-Ppbptm1(PPBP)Bcgen Pf4tm1(PF4)Bcgen/Bcgen • 112063

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B-hCXCL7 mice
B-hCXCR2 mice

B-hCXCL7/hCXCL4 mice

Product nameB-hCXCL7/hCXCL4 mice
Catalog number112063
Strain nameC57BL/6N-Ppbptm1(PPBP)Bcgen Pf4tm1(PF4)Bcgen/Bcgen
Strain backgroundC57BL/6N
AliasesPPBP (PBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7)PF4 (PF-4; CXCL4; SCYB4)
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  • Targeting strategy
  • Phenotypic analysis

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Targeting strategy

Gene targeting strategy for B-hCXCL7/hCXCL4 mice. The exons 1-3 of mouse Cxcl7 gene that encode the full-length protein and the exons 1-3 of mouse Cxcl4 gene that encode the full-length protein including the non-coding region between Cxcl7 gene and Cxcl4 gene were replaced by human CXCL7 exons 1-3 and human CXCL4 exons 1-3 in B-hCXCL7/hCXCL4 mice.

Protein expression analysis
Strain specific CXCL7 expression analysis in homozygous B-hCXCL7/hCXCL4 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hCXCL7/hCXCL4 mice (H/H), and analyzed by ELISA with species-specific CXCL7 ELISA kit. Mouse CXCL7 was detectable in wild-type mice. Human CXCL7 was exclusively detectable in homozygous B-hCXCL7/hCXCL4 mice but not in wild-type mice.
Strain specific CXCL4 expression analysis in homozygous B-hCXCL7/hCXCL4 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hCXCL7/hCXCL4 mice (H/H), and analyzed by ELISA with species-specific CXCL4 ELISA kit. Mouse CXCL4 was detectable in wild-type mice. Human CXCL4 was exclusively detectable in homozygous B-hCXCL7/hCXCL4 mice but not in wild-type mice.