B-hCXCL7 mice

C57BL/6N-Cxcl7tm1(CXCL7)Bcgen/Bcgen • 112404

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B-hCXCL3 mice
B-hCXCL7/hCXCL4 mice

B-hCXCL7 mice

Product nameB-hCXCL7 mice
Catalog number112404
Strain nameC57BL/6N-Cxcl7tm1(CXCL7)Bcgen/Bcgen
Strain backgroundC57BL/6N
AliasesPBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III
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  • Targeting strategy
  • Phenotypic analysis

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Targeting strategy

Gene targeting strategy for B-hCXCL7 mice. The exons 1~3 of mouse Cxcl7 gene that encode the full-length protein were replaced by human CXCL7 exons 1~3 in B-hCXCL7 mice.

Protein expression analysis
Strain specific CXCL7 expression analysis in homozygous B-hCXCL7 mice by ELISA. Serum were isolated from wild-type C57BL/6 mice (+/+) and homozygous B-hCXCL7 mice (H/H) and analyzed by ELISA with species-specific CXCL7 ELISA kit. Mouse CXCL7 was detectable in wild-type mice (A). Human CXCL7 was exclusively detectable in homozygous B-hCXCL7 mice (B).