Animal Models & Cell Lines

Immunodeficient Models

Humanized immunodeficient mice offer a versatile in vivo model for the assessment of human-based immunotherapies. At Biocytogen, our scientific team independently designed and generated the severely immunodeficient B-NDG mouse model (NOD.CB17-Prkdcscid Il2rgtm1Bcgen/Bcgen). B-NDG mice lack mature T cells, B cells, and functional NK cells, and also exhibit cytokine signaling deficiencies. These combined characteristics confer the highest degree of immunodeficiency, making B-NDG mice ideal for engraftment and growth of human hematopoietic stem cells (HSCs), peripheral blood mononuclear cells (PBMCs), and human tumor cells or tissues. Building upon the B-NDG platform, Biocytogen has developed a series of second-generation humanized mouse models tailored for diverse research applications. These immunodeficient animal models serve as essential tools for evaluating immuno-oncology therapeutics.

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  • Key Features of Biocytogen's Immunodeficient Models
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      Key Features of Biocytogen's Immunodeficient Models
      • Holds the highest degree of immunodeficiency among all immunodeficient mouse models.
      • Longer lifespan than NOD-scid or NSG mouse models (average 1.5 years).
      • Minimal to no rejection of human-derived cells and tissues.
      • Highly efficient for CDX and PDX model generation using humanized mice
      • No B lymphocyte leakage.
      • Excellent engraftment efficiency for both human immune cells and tumor tissues.
      To overcome challenges in immune system reconstruction within severely immunodeficient humanized mouse models, Biocytogen developed next-generation models based on B-NDG mice. These innovative animal models are highly suitable for tumor immunotherapy, infectious disease research, and autoimmune studies, providing robust and reproducible data for translational applications.
      Building on our gene-editing expertise, Biocytogen can also create custom knock in mouse lines on immunodeficient backgrounds for mechanistic studies and in vivo model development.
      Why Choose Biocytogen's Immunodeficient Mouse Models?
      With over a decade of experience in humanized animal model development, Biocytogen offers customized immunodeficient mouse models that accelerate drug discovery pipelines.
      Our immunodeficient mouse platform supports:
      • Evaluation of immune checkpoint inhibitors
      • Study of human immune–tumor interactions
      • Assessment of antibody efficacy and safety
      • Testing of cell-based therapies, including CAR-T and CAR-NK
      Biocytogen continues to expand its portfolio of immunodeficient mouse models to address a wide range of therapeutic areas, delivering scientifically validated, reproducible, and translationally relevant results.
      Featured Products
      Product List
        Product Name Product No. Background Actions
        B-BDG mice 114251 BALB/cCrSlcNifdc
        B-CDG mice 112937 C57BL/6N
        B-Ces1c KO mice(CB-17 SCID) 112622 CB-17 SCID
        B-Fcgr4 KO mice(CB-17 SCID) 111654 CB-17 SCID
        B-FcRn KO mice(CB-17 SCID) 114057 CB-17 SCID
        B-hCD16A mice plus(CB-17 SCID) 113688 CB-17 SCID
        B-hCD16A mice(CB-17 SCID) 111174 CB-17 SCID
        B-hCD16A/hNKP46 mice(CB-17 SCID) 112987 CB-17 SCID
        B-hCD98HC/Rag2 KO mice 112326 C57BL/6N
        B-hFcRn, Ces1c KO mice(CB-17 SCID) 114091 CB-17 SCID
        B-hFcRn, Rag2 KO mice 113288 C57BL/6
        B-hFcRn, Rag2 KO rats 114185 SD
        B-hIL23A/hIL12B, Rag2 KO mice 113953 C57BL/6
        B-hNCR3 mice(CB-17 SCID) 112931 CB-17 SCID
        B-hNKP46 mice(CB-17 SCID) 112259 CB-17 SCID
        B-hPSGL-1, Rag2 KO mice 114033 C57BL/6N
        B-hSIRPA/hCD47, Prkdc KO mice 130565 C57BL/6
        B-hSIRPA/hCD47,Il2rg KO mice 130566 C57BL/6
        B-hTFR1, Rag2 KO mice 112904 C57BL/6
        B-hTL1A, Rag2 KO mice 114011 C57BL/6N
        B-IL2rg KO rats 210513 SD
        B-NDG B2m KO mice plus 110601 B-NDG
        B-NDG B2m plus/hIL15 mice 111856 B-NDG
        B-NDG Ces1c KO mice 112623 B-NDG
        B-NDG FcγR KO mice 112839 B-NDG
        B-NDG Flt3 KO mice 112869 B-NDG
        B-NDG H2-Ab1 KO mice 110595 B-NDG
        B-NDG H2-K1/H2-D1 KO mice 112256 B-NDG
        B-NDG hairless mice 110598 B-NDG
        B-NDG hALB mice 111982 B-NDG
        B-NDG hALB/hFcRn mice 112774 B-NDG
        B-NDG hB2M/HLA-A11.1 mice 112451 B-NDG
        B-NDG hB2M/HLA-A11.1 mice plus 112474 B-NDG
        B-NDG hB2M/HLA-A2.1 mice plus 112449 B-NDG
        B-NDG hB2M/HLA-A24.2 mice 112560 B-NDG
        B-NDG hB2M/HLA-A24.2 mice plus 112874 B-NDG
        B-NDG hB2M/HLA-A3.1 mice 112450 B-NDG
        B-NDG hB2M/HLA-A3.1 mice plus 112873 B-NDG
        B-NDG Hc mice 110605 B-NDG
        B-NDG hCD70 mice(NOD.Cg) 113504 B-NDG
        B-NDG hCD89 mice 114086 NOD.CB17
        B-NDG hCD98HC mice 113117 B-NDG
        B-NDG hCDH3 mice 113230 B-NDG
        B-NDG hCLDN6 mice 113235 B-NDG
        B-NDG hCRBN mice 113931 B-NDG
        B-NDG hCSF1 mice 110591 B-NDG
        B-NDG hCSF1/hTHPO mice 120609 B-NDG
        B-NDG hDLL3 mice 113234 B-NDG
        B-NDG hEGFR mice 113309 NOD
        B-NDG hEPCAM mice 112660 B-NDG
        B-NDG hEPO mice 113530 B-NDG
        B-NDG hF3 mice 113228 B-NDG
        B-NDG hFAP mice 113550 B-NDG
        B-NDG hFcRn mice 111922 B-NDG
        B-NDG hFLT3LG, Flt3 KO mice 112889 B-NDG
        B-NDG hGM-CSF mice 110593 B-NDG
        B-NDG hGPC3 mice 113231 NOD
        B-NDG hHER2 mice 112866 B-NDG
        B-NDG hHER3 mice 113220 B-NDG
        B-NDG hIL15 mice 110600 B-NDG
        B-NDG hIL15, FcγR KO mice 112653 B-NDG
        B-NDG hIL15, MHC I/II DKO ad mice 114071 B-NDG
        B-NDG hIL2 mice 113385 B-NDG
        B-NDG hIL34 mice 113407 B-NDG
        B-NDG hIL5 mice 113774 B-NDG
        B-NDG hIL6 mice 110596 B-NDG
        B-NDG hIL7 mice 110597 B-NDG
        B-NDG hIL7/hIL15 mice 120612 B-NDG
        B-NDG HLA-A2.1 mice 110599 B-NDG
        B-NDG hLy6E mice 113237 B-NDG
        B-NDG hMUC1 mice 113229 B-NDG
        B-NDG hNECTIN4 mice 113179 B-NDG
        B-NDG hNTCP mice 113352 B-NDG
        B-NDG hSIRPA mice 110604 B-NDG
        B-NDG hSIRPA/hCD47 mice 110603 B-NDG
        B-NDG hTFR1 mice plus 113863 B-NDG
        B-NDG hTHPO mice 110590 B-NDG
        B-NDG hTHPO/hSCF mice 113801 NOD
        B-NDG hTHPO/hSCF/hIL3/hGM-CSF mice 114586 NOD
        B-NDG hTPBG mice 113221 B-NDG
        B-NDG hTROP2 mice 113178 B-NDG
        B-NDG hUPAR mice 113376 B-NDG
        B-NDG hVEGFA mice 113341 NOD/SCID
        B-NDG Idua*W392X mice 113531 B-NDG
        B-NDG Kit W41 mice 112914 B-NDG
        B-NDG MGMT3 mice 111882 B-NDG
        B-NDG MHC I/II DKO mice ad 112946 B-NDG
        B-NDG MHC I/II DKO mice plus 111895 B-NDG
        B-NDG MHC I/II DKO/hB7-H3 mice 112705 B-NDG
        B-NDG MHC I/II DKO/hMSLN mice 112704 B-NDG
        B-NDG MHC I/II DKO/hMSLN/hB7-H3 mice 114084 B-NDG
        B-NDG mice 110586 NOD/SCID
        B-NDG nude mice 110587 B-NDG
        B-NDG Tg(RORγt-Il2rg) mice 112590 B-NDG
        B-NODG mice 114117 B-NDG
        B-nude rats 112457 SD
        B-Rag2 KO mice 110809 C57BL/6
        B-Rag2 KO mice(C) 112883 BALB/cCrSlcNifdc
        B-Rag2 KO rats 210511 SD
        B-Rag2/F8 DKO mice 112250 C57BL/6
        B-SDG rats 210512 SD
        huHSC-B-NDG hB2M/HLA-A2.1 mice plus 114148 B-NDG
        huHSC-B-NDG hCSF1/hTHPO mice 112863 B-NDG
        huHSC-B-NDG hFLT3LG, Flt3 KO mice 115048 B-NDG
        huHSC-B-NDG hIL15 mice 112478 B-NDG
        huHSC-B-NDG hIL15, FcγR KO mice 114031 B-NDG
        huHSC-B-NDG hIL6 mice 112864 B-NDG
        huHSC-B-NDG HLA-A2.1 mice 112865 B-NDG
        huHSC-B-NDG hTHPO mice 112480 B-NDG
        huHSC-B-NDG MGMT3 mice 112479 B-NDG
        huHSC-B-NDG mice 112470 NOD/SCID
        huNK-B-NDG hIL15 mice 112482 B-NDG
        huPBMC-B-NDG B2m KO mice plus 112484 B-NDG
        huPBMC-B-NDG hIL15, FcγR KO mice 114234 B-NDG
        huPBMC-B-NDG hIL15, MHC I/II DKO ad mice 115090 B-NDG
        huPBMC-B-NDG MHC I/II DKO mice ad 114316 B-NDG
        huPBMC-B-NDG MHC I/II DKO mice plus 112483 B-NDG
        huPBMC-B-NDG mice 112469 NOD/SCID