Autoimmune diseases and other inflammatory disorders are mediated by dysfunction of the body’s immune system, typically in the form of hypersensitivity. These disorders are subject to intensive research and drug development efforts, and require extensive study in mouse models of inflammation. Biocytogen provides robust inflammation models, including those designed to experimentally model experimental autoimmune encephalomyelitis (EAE), psoriasis, asthma, and other diseases in mice. Novel anti-human inflammatory modulators can also be tested in our humanized cytokine/cytokine receptor mouse models. These mouse models of inflammation allow researchers to evaluate the preclinical efficacy of therapeutics against specific human targets in mice critical to the underlying molecular mechanisms of autoimmune and inflammatory diseases.
For a full list of our humanized cytokine models, click here.
Watch the webinar: Investigating Inflammatory Disease using Humanized Cytokine Mice
Chronic MOG-induced EAE model in human IL-17A knock-in mice (B-hIL17A) expressing human IL-17ALearn More
Ovalbumin-induced asthma model in double human IL-4 and IL-4RA knock-in mice (B-hIL4&hIL4RA) expressing both human IL-4 and human IL-4RALearn More
A Imiquimod-induced psoriasis in human IL-17A knock-in mice (B-hIL17A) expressing human IL-17ALearn More
Atopic Dermatitis Model
Induced by enhanced skin sensitization using epithelial sensitive antigens, haptens, etc. Offering genetically engineered and spontaneous AD mouse modelsLearn More
Rheumatoid Arthritis Model
Established stable CIA disease models in different strains of mice (C57BL/6, DBA), which can be used for pharmacodynamic evaluation of rheumatoid arthritis related drugsLearn More