Atherosclerosis model

A mouse model of atherosclerosis includes genetic deletion of Apoe, which results in increased levels of plasma cholesterol.

Atherosclerosis is an immunometabolic disease driven by the retention of cholesterol-rich, apolipoprotein B-containing lipoproteins. A mouse model of atherosclerosis includes genetic deletion of Apoe, which results in increased levels of plasma cholesterol. Feeding ApoE KO mice with a high cholesterol diet exacerbates atherosclerosis development. 

 

Special diet-induced atherosclerosis in ApoE knockout mice. (A-B) Atherosclerotic plaques in ApoE KO mice with (model) or without (control) a special diet (40% fat, 43% carbohydrate and 1.5% cholesterol) at 12 and 20 weeks. (C-D) Oil Red results of aortic sinus at 12 and 20 weeks. (E) Gross staining of aortic arch at 12 weeks.

Tissue staining and blood biochemical results in a mouse model of atherosclerosis at 12 weeks (A) H&E results showed increased aortic sinus in ApoE KO mice with a special diet. (B-C) Immunohistochemistry showed expression of α-SMA and F4/80. (D) ALT, AST, TC, TG, HDL-C and LDL-C serum levels in ApoE KO mice wth special diets. Values are expressed as mean ± SEM. **p<0.01, ****p<0.0001.

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