G protein-coupled receptors (GPCRs) play an integral role in transmitting cellular growth and migration signals in a variety of biological contexts. Alterations in GPCR signaling are associated with immune dysregulation and cancer progression, making GPCRs attractive drug targets. However, the complex biochemical structure and shared homology among family members has made targeting GPCRs difficult. Biocytogen has engineered several strains of humanized GPCR mice to test human GPCR drug candidates. Use of our humanized GPCR models allows for comprehensive safety, dosing, and efficacy testing of your therapeutic candidates prior to clinical development.
Humanized GPCR Mice
| Product | Product No | Background |
|---|---|---|
| B-hA2AR mice | 110120 | C57BL/6 |
| B-hADGRG2 mice | 112431 | C57BL/6 |
| B-hADORA2B mice | 112583 | C57BL/6 |
| B-hADRB1 mice | 111897 | C57BL/6N |
| B-hBDKRB2 mice | 112355 | C57BL/6N |
| B-hC5AR1 Mice | 110078 | C57BL/6 |
| B-hC5AR2 mice | 111001 | C57BL/6N |
| B-hCALCRL mice | 110115 | C57BL/6 |
| B-hCB1 mice | 110943 | C57BL/6N |
| B-hCB2 mice | 111000 | C57BL/6N |
| B-hCCL20 mice | 110854 | C57BL/6N |
| B-hCCR1 mice | 111191 | C57BL/6N |
| B-hCCR2 mice | 110097 | C57BL/6N |
| B-hCCR3 mice | 111401 | C57BL/6N |
| B-hCCR4 mice | 110098 | C57BL/6 |
| B-hCCR5 mice | 110099 | C57BL/6 |
| B-hCCR6 mice | 110853 | C57BL/6N |
| B-hCCR7 mice | 111557 | C57BL/6N |
| B-hCCR8 mice | 110096 | C57BL/6 |
| B-hCCR8 mice(C) | 112487 | BALB/cCrSIcNifdc |
| B-hCCR8/hCCL1 mice | 121836 | C57BL/6 |
| B-hCCR9 mice | 110972 | C57BL/6N |
| B-hCGRP mice | 110118 | C57BL/6N |
| B-hCMKLR1 mice | 112875 | C57BL/6N |
| B-hCRTH2 mice plus | 112547 | C57BL/6N |
| B-hCX3CR1 mice | 110101 | C57BL/6 |
| B-hCXCL13/hCXCR5 mice | 111189 | C57BL/6N |
| B-hCXCR2 mice | 110816 | C57BL/6 |
| B-hCXCR3 mice | 110969 | C57BL/6N |
| B-hCXCR4 mice | 110100 | C57BL/6 |
| B-hCXCR5 mice | 110970 | C57BL/6N |
| B-hCXCR6 mice | 111186 | C57BL/6N |
| B-hETAR mice | 110108 | C57BL/6 |
| B-hF2RL1 mice | 112362 | C57BL/6 |
| B-hFSHR mice | 112061 | C57BL/6N |
| B-hFXI mice | 112749 | C57BL/6 |
| B-hFZD5 mice | 112546 | C57BL/6N |
| B-hFZD7 mice | 112674 | C57BL/6N |
| B-hGCGR mice | 110105 | C57BL/6 |
| B-hGIPR mice | 112714 | C57BL/6 |
| B-hGLP1R mice | 170164 | C57BL/6J |
| B-hGLP1R/hGCGR mice | 121837 | C57BL/6 |
| B-hGPR20 mice | 112629 | C57BL/6N |
| B-hGPR35 mice | 111171 | C57BL/6N |
| B-hGPR40 mice | 111595 | C57BL/6N |
| B-hGPR55 mice | 112462 | C57BL/6N |
| B-hGPR75 mice | 112305 | C57BL/6JNifdc |
| B-hGPR87 mice | 112529 | C57BL/6N |
| B-hGPRC5D mice | 111240 | C57BL/6N |
| B-hLGR4 mice | 110968 | C57BL/6 |
| B-hMC4R mice | 112592 | C57BL/6N |
| B-hPAC1R mice | 112123 | C57BL/6 |
| B-hRSPO3/hLGR5 mice | 110857 | C57BL/6 |
| B-hS1PR1 mice | 111029 | C57BL/6N |
| B-hSUCNR1 mice | 111009 | C57BL/6N |
| B-hVPAC1 mice | 112336 | C57BL/6 |
