Humanized GPCR Mice

G protein-coupled receptors (GPCRs) play an integral role in transmitting cellular growth and migration signals in a variety of biological contexts. Alterations in GPCR signaling are associated with immune dysregulation and cancer progression, making GPCRs attractive drug targets. However, the complex biochemical structure and shared homology among family members has made targeting GPCRs difficult. Biocytogen has engineered several strains of humanized GPCR mice to test human GPCR drug candidates. Use of our humanized GPCR models allows for comprehensive safety, dosing, and efficacy testing of your therapeutic candidates prior to clinical development.

Humanized GPCR Mice

Product Product No Background
B-hA2AR mice 110120 C57BL/6
B-hC5AR1 Mice 110078 C57BL/6
B-hCALCRL mice 110115 C57BL/6
B-hCB1 mice 110943 C57BL/6
B-hCCR2 mice 110097 C57BL/6
B-hCCR4 mice 110098 C57BL/6
B-hCCR5 mice 110099 C57BL/6
B-hCCR6 mice 110853 C57BL/6
B-hCCR8 mice 110096 C57BL/6
B-hCLDN6 mice 111086 C57BL/6
B-hCRTH2 mice 111060 C57BL/6
B-hCX3CR1 mice 110101 C57BL/6
B-hCXCR2 mice 110816 C57BL/6
B-hCXCR4 mice 110100 C57BL/6
B-hCXCR5 mice 110970 C57BL/6
B-hETAR mice 110108 C57BL/6
B-hGCGR mice 110105 C57BL/6
B-hGLP1R mice 170164 C57BL/6