Immune system-reconstituted models for immuno-oncology research: Applications of CD34+ humanized B-NDG mice
May 5, 2023
Introduction: Choosing the right humanized model for your study The relative success of immuno-oncology drugs has directed research toward discovering novel targets and therapeutic agents. This has also resulted in heightened demands for the establishment and utilization of relevant, robust animal models for in vivo evaluation of novel preclinical drug candidates. With the shift toward […]
Humanized PCSK9 mice as a resource for lipid management studies
April 24, 2023
Introduction: mitigating dyslipidemia to prevent cardiovascular disease Dyslipidemia is a metabolic derangement that clinically presents with abnormal levels of lipids (cholesterol, triglycerides, and/or phospholipids) in the blood. Specifically, the condition is marked by high levels of low-density lipoprotein (LDL) and low levels of high-density lipoprotein (HDL) cholesterol. Of note, high levels of LDL cholesterol are […]
2023 Popular Mouse Models and Cell Lines
March 28, 2023
Our advanced genome editing technologies have been leveraged by our own development scientists to create hundreds of animal and cell models used in biomedical research all over the world. 13 years since our founding, Biocytogen’s catalog of off-the-shelf gene-edited animal models, BioMice, now contains more than 450 strains. From knock-outs to humanized knock-ins, our models are […]
Selecting the Right Platform for Your Antibody Discovery Project
November 17, 2022
Contributed by John Charpentier, Ph.D. and Li Hui, M.D., Ph.D. The variety of technology platforms available for therapeutic antibody discovery can be both exciting and daunting. Here we provide some general guidelines to help investigators understand their capabilities and applications. Since the introduction of hybridoma technology in the 1970s, numerous antibody discovery platforms have been […]
Development History of Immunodeficient Mice and Their Research Applications
October 25, 2022
By John Charpentier, Ph.D. October 25, 2022 Since the characterization of the nude mouse in 1962, genetic mouse models of immunodeficiency have been increasingly developed, diversified, and utilized for both basic discovery research and preclinical studies of therapeutic candidates. Today, highly immunodeficient, genetically-engineered mouse models are invaluable tools for basic biomedical research, especially for the […]
Research Impact: B-NDG Mice Used to Identify Lipid Transport Mechanism Driving T Cell Leukemogenesis
September 29, 2022
By John Charpentier, Ph.D. September 29, 2022 A recent study featuring Biocytogen mice identifies a non-vesicular lipid transport mechanism required for T cell leukemogenesis. Wenbing Zhong and colleagues at Jinan University in Guangzhou, China report that a lipid binding protein called ORP4L, which is expressed in adult T cell leukemia (ATL) cells but not normal […]
Research Impact: Custom Biocytogen mouse models used to identify critical mediator of inflammation-driven metastases
September 7, 2022
By John Charpentier, Ph.D. September 7, 2022 While metastases are ultimately responsible for the large majority of cancer deaths, most oncology drugs in development target primary tumors, and few specifically prevent metastasis. Although surgical resection of solid tumors is an effective early treatment intervention, the resulting inflammation can promote metastasis by increasing adhesion of circulating […]
2022 Popular Mouse Models and Cell Lines
August 11, 2022
Biocytogen’s advanced genome editing technologies have been leveraged by our own development scientists to create hundreds of animal and cell models used in biomedical research all over the world. 13 years since our founding, Biocytogen’s catalog of off-the-shelf gene-edited animal models, BioMice, now contains more than 450 strains. From knock-outs to humanized knock-ins, our models […]
First Half of 2022 Publications Highlight
August 8, 2022
Our off-the-shelf and custom animal and cell models are advancing cutting-edge biomedical research every day. One measure of this impact is how often they appear in high impact publications and journals. Check out the list of studies published so far this year which feature Biocytogen models: B-hCD3E Mice Zhang, R., Zhang, J., Zhou, X. et […]
2021 Highlights: Humanized Model Publications
December 8, 2021
We are proud to highlight our growing list of publications featuring off-the-shelf and customized mouse, rat, and cancer cell models in well-respected, high-impact journals. Featured below is a selection of publications throughout 2021 that used our humanized mouse models. Congratulations to our colleagues who have contributed to these exciting results! Humanized B-h4-1BB Mice Hurov K, Lahdenranta […]
