In vivo Animal and Cell Models

We provide a number of genetically-modified animal models including humanized immune-checkpoint mouse models, humanized cytokine mice, drug target humanized mice, and humanized cell lines for basic and preclinical research.

Developing a new drug for human use is a lengthy and costly process that takes an average of 10 years or more and costs approximately $2.6 billion. Yet, when one considers the number of people a successful drug can help, the return on investment can be astounding.

Before a drug goes to market, its efficacy, safety, and mechanism of action (MOA) must be thoroughly understood. Animal models for research work to minimize adverse side effects and maximize therapeutic properties of a drug before it is taken to clinical trials. Biocytogen is a one-stop CRO that provides humanized mouse models for immuno-oncology and autoimmune/inflammatory disease targets, which can help move projects from target to IND application.

Animal Models for Research

Although scientists have made significant technological advancements for in vitro models and methods, those applications are limited when it comes to human translational research. Moreover, ethical and safety concerns require that drugs be proven safe with certain levels of efficacy before they are approved for medical use. To profile drugs, toxicology and efficacy studies are primarily performed in animal models for research. As such, in vivo models are indispensable in preclinical profiling, especially in cancer research and drug development.

Main Categories
Sub Categories
Humanized animal models Humanized Immune-Checkpoint Mice
Humanized Cytokine Mice
Humanized GPCR Mice
Other Humanized Models
Immunodeficient Models Immunodeficient mice (B-NDG background)
Immunodeficient mouse models (non B-NDG background)
Tool Models
Reporter Models
Cre Models
DTR Models
Other Tool Models
Disease Mouse Models Disease Mouse Models
KO Mouse Models Drug Target Knockout Mice
Other Knockout Mice
Cell Lines
Humanized Tumor Cell Lines
Other Cancer Cell Lines


Anatomically and physiologically speaking, humans and animals are very similar as they share the same organs and organ systems that perform similar life functions. Particularly, rodents such as mice and rats are practical as in vivo models. Although non-human primates are still primarily used for IND-enabling studies, supply shortages have led to the alternative use of genetically modified rodents.  

Biocytogen provides a number of genetically-modified in vivo models for basic and preclinical research, which includes syngeneic mouse models and xenografts. Syngeneic mouse tumor models are defined as mice inoculated with tumor cells that are from the same genetic background. Syngeneic mouse models have an intact immune system, allowing them to be used for efficacy assessment and screening tools for immunotherapies. Our humanized immune checkpoint mouse models, engineered to express human forms of immune signaling molecules, are ideal for studying anti-human antibody activity. We also offer other humanized models expressing common tumor cell-associated antigens (TAA).

To date, many pharmaceutical companies have received Investigational New Drug (IND) approval with the help of BioMice’s target humanized mice for RDT and DART studies.  As a leader in the field of humanized model generation, we have ownership of intellectual property for our products, under which use of these models by our clients is protected.

In contrast to syngeneic models, xenograft models use cells from one species to transplant into another, often human cells into an immunodeficient mouse. Depending on whether the cells come from a patient or an established cell line, patient-derived xenografts (PDX) and cell-derived xenografts (CDX) can allow in vivo testing of anti-cancer treatments on human tumors. Through adoptive transfer of human-derived cells or tissue into the highly immune-deficient B-NDG™ mouse, human immune systems can be reconstituted and studied in vivo

Cell Line Engineering Services

Cell line engineering — also referred to as cell line editing — involves the genetic altering of cell lines to determine the effects of a specific alteration. In studying phenotypic changes of these cells, scientists can drive the discovery of new drugs and therapies for various types of cancer cells. Biocytogen has more than a decade of experience engineering a wide range of cell lines, ranging from HeLa, 293FT and HEK 293 to more challenging-to-confect cell lines such as fibroblasts, endothelium-derived, neuroblastoma-derived, bone-marrow-derived, hepatocellular-carcinoma-derived cells, and hiPSC.

Biocytogen — A World Leader in Animal & Cell Line Engineering Services

Biocytogen has been serving customers around the world, both in academia and industry, for over a decade. With our commitment to quality in everything we do, we’ll work closely with you to deliver models and services that meet your precise specifications in a timely manner. We offer world-leading, cutting-edge technology platforms, superior service, a fast timeline, a large collection of animal models for research and a 100 percent satisfaction guarantee.

We have established a world-class animal model production center, including three animal faculties encompassing a total of approximately 55,000 sq. m., with an annual supply capacity of 800,000 gene-edited mice. Shipping is available to our customers worldwide. 

For more information about our products and services, contact us today

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