Humanized Immune-Checkpoint Mice

Immuno Oncology Mouse Models

Cancer immunotherapy is one of the most promising research areas in the field of cancer therapy, with immuno-oncology mouse models at the helm of available research tools. Major pharmaceutical companies in the world have devoted great efforts to developing cancer immunity-related treatment methods, with clinical trial results showing that treatment efficacy is very high. Furthermore, Science magazine ranked cancer immunotherapy to be first place among the top ten scientific breakthroughs in 2013.

Immune-checkpoints are molecules in the immune system that either turn up (co-stimulatory molecules) or turn down (inhibitory molecules) immune signals. Tumors can use these checkpoints to protect themselves from immune system attacks, particularly by T cells. Checkpoint therapy can block inhibitory checkpoints or activate stimulatory molecules, restoring immune system function.  In recent years, immune-checkpoint drugs have become an important novel cancer treatment, as well as immuno-oncology mouse models. Biocytogen has generated and validated a series of humanized immune-checkpoint mice that can serve as immuno-oncology mouse models for in vivo efficacy evaluation of human immune-checkpoint drug candidates.

Key features of Biocytogen’s humanized immune-checkpoint mice:

  • Pure C57BL/6 genetic background leads to more consistent and reliable experimental results. Biocytogen’s humanized immune-checkpoint mice are developed using the C57BL/6 genetic background, which is commonly used in oncology, physiology, immunology and genetics studies.
  • Our humanized mice are carefully designed and generated to maintain biological functions and ensure more reliable drug validation. Biocytogen has developed a wealth of experience in animal model development, with specific experience in humanized immuno-oncology mouse model design. Our experts fully consider all factors that may interfere with the expression of humanized proteins and design a detailed, scientifically accurate plan to ensure sufficient humanization, humanized protein expression, and intact signal transduction. With humanized mice, in vivo efficacy evaluation of humanized immune-checkpoint antibodies or inhibitors becomes even more reliable and dependable.

Single Humanized Immune-checkpoint Mice

Product Product No Background
B-HLA-A2.1 Mice 110110 C57BL/6N
B-dPD-1 mice 110022 C57BL/6
B-h4-1BB mice 110004 C57BL/6
B-h4-1BB mice(C) 112652 BALB/cCrSIcNifdc
B-hADRB1 mice 111897 C57BL/6N
B-hALCAM mice 111146 C57BL/6J
B-hAMHR2 mice 111143 C57BL/6N
B-hANTXR2 mice 112044 C57BL/6
B-hAXL mice 110908 C57BL/6
B-hB7-H3 mice 110028 C57BL/6
B-hB7-H3 mice (C) 111806 BALB/cCrSlcNifdc
B-hB7-H4 mice 110045 C57BL/6J
B-hBCMA mice 110899 C57BL/6N
B-hBDCA2 mice 112058 C57BL/6
B-hBST2 mice 112095 C57BL/6N
B-hBTLA mice 110005 C57BL/6N
B-hCD147 mice 110995 C57BL/6N
B-hCD155 mice 110759 C57BL/6
B-hCD160 mice 111900 C57BL/6JNifdc
B-hCD163 mice 111298 C57BL/6
B-hCD16A mice 111173 C57BL/6N
B-hCD16A mice(C) 111885 BALB/cCrSlcNifdc
B-hCD16A mice(CB-17 SCID) 111174 CB-17 SCID
B-hCD16B mice 111863 C57BL/6
B-hCD180 mice 111221 C57BL/6N
B-hCD19 mice 112657 C57BL/6JNifdc
B-hCD2 mice 111132 C57BL/6N
B-hCD20 mice 111231 C57BL/6N
B-hCD200 mice 111133 C57BL/6
B-hCD200R mice 111131 C57BL/6N
B-hCD22 mice 110775 C57BL/6
B-hCD226 mice 110869 C57BL/6N
B-hCD23 mice 111091 C57BL/6N
B-hCD24 mice plus 111953 C57BL/6N
B-hCD248 mice 111059 C57BL/6N
B-hCD27 mice 110006 C57BL/6
B-hCD28 mice 110007 C57BL/6N
B-hCD30 mice 110888 C57BL/6
B-hCD32A mice 112051 C57BL/6
B-hCD32B mice 112052 C57BL/6JNifdc
B-hCD33 mice 110823 C57BL/6
B-hCD36 mice 111045 C57BL/6
B-hCD37 mice 110856 C57BL/6N
B-hCD39 mice 110783 C57BL/6
B-hCD3E mice 110008 C57BL/6
B-hCD3EDG mice 110039 C57BL/6
B-hCD4 mice 110842 C57BL/6
B-hCD40 mice 110009 C57BL/6N
B-hCD40L mice 110756 C57BL/6J
B-hCD43 mice 110892 C57BL/6N
B-hCD44 mice 110961 C57BL/6
B-hCD45 mice 110973 C57BL/6
B-hCD47 mice 110010 C57BL/6N
B-hCD47 mice(C) 110615 BALB/cCrSlcNifdc
B-hCD48 mice 111141 C57BL/6
B-hCD5 mice 111125 C57BL/6N
B-hCD52 mice 110860 C57BL/6N
B-hCD6 mice 111145 C57BL/6N
B-hCD69 mice 111614 C57BL/6N
B-hCD70 mice 110770 C57BL/6J
B-hCD73 mice 110027 C57BL/6
B-hCD79B mice 111096 C57BL/6N
B-hCD80 mice 110935 C57BL/6
B-hCD89 mice 110864 C57BL/6N
B-hCD93 mice 111135 C57BL/6N
B-hCD94 mice 110044 C57BL/6
B-hCD95 mice 111970 C57BL/6
B-hCD98HC mice 110983 C57BL/6N
B-hCDCP1 mice 112648 C57BL/6
B-hCEACAM1 mice 111073 C57BL/6
B-hCLEC10A mice 112543 C57BL/6N
B-hCLEC14A mice 112049 C57BL/6N
B-hCLEC9A mice 111994 C57BL/6N
B-hCLU mice 111430 C57BL/6
B-hCSF1 mice 110799 C57BL/6
B-hCSPG4 mice 111104 C57BL/6
B-hCTLA4 mice 110011 C57BL/6N
B-hCTLA4 mice(C) 112755 BALB/cCrSlcNifdc
B-hCX3CL1 mice 111257 C57BL/6N
B-hDDR1 mice 111121 C57BL/6N
B-hDLL1 mice 111369 C57BL/6N
B-hDLL3 mice 110926 C57BL/6N
B-hDLL4 mice 112067 C57BL/6
B-hDR4 mice 111986 C57BL/6
B-hEBI3 mice 110764 C57BL/6
B-hEPCAM mice 110826 C57BL/6
B-hF11R mice 112164 C57BL/6N
B-hFAP mice 110831 C57BL/6
B-hFGL1 mice 110116 C57BL/6
B-hFGL2 mice 111190 C57BL/6N
B-hFOLR4 mice 111041 C57BL/6N
B-hGARP mice 110102 C57BL/6
B-hGAS6 mice 110985 C57BL/6
B-hGITR mice 110012 C57BL/6N
B-hGPC3 mice 110873 C57BL/6N
B-hHCAR1 mice 111919 C57BL/6N
B-hICAM1 mice 111242 C57BL/6N
B-hICAM3 mice 111243 C57BL/6
B-hICOSL mice 110037 C57BL/6
B-hITGA5 mice 111254 C57BL/6
B-hITGB3 mice 112329 C57BL/6JNifdc
B-hITGB7 mice 111246 C57BL/6N
B-hITGB8 mice 111284 C57BL/6J
B-hJAM3 mice 111256 C57BL/6N
B-hKAAG1 mice 112188 C57BL/6N
B-hKLRG1 mice 112420 C57BL/6
B-hLAG3 mice plus 110025 C57BL/6
B-hLGALS9 mice 112053 C57BL/6J
B-hLIGHT mice 110944 C57BL/6N
B-hLRRC33 mice 110757 C57BL/6
B-hLY6E mice 112228 C57BL/6N
B-hMADCAM1 mice 111627 C57BL/6N
B-hMARCO mice 111341 C57BL/6N
B-hMCAM mice 111168 C57BL/6N
B-hMELTF mice 111964 C57BL/6
B-hMERTK mice 111278 C57BL/6N
B-hMICA mice 112161 C57BL/6
B-hMMP9 mice 112050 C57BL/6N
B-hMRC1 mice 111223 C57BL/6
B-hMUC1 mice 110867 C57BL/6
B-hNCR2 mice 111872 C57BL/6
B-hNCR3 mice 112190 C57BL/6
B-hNKG2A mice 110041 C57BL/6N
B-hNKG2D mice 111188 C57BL/6N
B-hNKG2D mice plus 112497 C57BL/6
B-hNKP46 mice 111946 C57BL/6JNifdc
B-hNKP46 mice(C) 112004 BALB/cCrSlcNifdc
B-hNOTCH1 mice 110904 C57BL/6
B-hNRP1 mice 111330 C57BL/6
B-hNTRK1 mice 110810 C57BL/6J
B-hOX40 mice 110014 C57BL/6N
B-hPD-1 mice 110003 C57BL/6N
B-hPD-1 mice Plus 110019 C57BL/6N
B-hPD-1 mice(C) 112015 BALB/cCrSlcNifdc
B-hPD-L1 mice 110015 C57BL/6N
B-hPD-L1 mice(C) 112016 BALB/cCrSlcNifdc
B-hPDGFB mice 111649 C57BL/6
B-hPDGFRA mice 111709 C57BL/6
B-hPDGFRB mice 111317 C57BL/6N
B-hPDPN mice 111099 C57BL/6N
B-hPSGL-1 mice 111470 C57BL/6N
B-hPVRIG mice 110091 C57BL/6J
B-hRAGE mice 111107 C57BL/6N
B-hRANKL mice 111072 C57BL/6
B-hROBO4 mice 111022 C57BL/6N
B-hRTN4R mice 111214 C57BL/6N
B-hSELP mice 110836 C57BL/6
B-hSEMA4D mice 112334 C57BL/6
B-hSIGLEC10 mice 110843 C57BL/6N
B-hSIGLEC15 mice 110121 C57BL/6N
B-hSIRPA mice 110016 C57BL/6N
B-hSRB1 mice 111115 C57BL/6
B-hTF mice 110967 C57BL/6N
B-hTFPI mice 111232 C57BL/6
B-hTFR1 mice 110861 C57BL/6
B-hTGFB1 mice 112245 C57BL/6N
B-hTGFBR2 mice 110874 C57BL/6N
B-hTIGIT mice 110017 C57BL/6N
B-hTIGIT mice(C) 112252 BALB/cCrSlcNifdc
B-hTIM3 mice 110018 C57BL/6N
B-hTIM4 mice 110837 C57BL/6
B-hTL1A mice 111997 C57BL/6N
B-hTLR2 mice 111228 C57BL/6N
B-hTLR8 Mice 110104 C57BL/6
B-hTLR9 mice 110103 C57BL/6
B-hTNFR2 mice 110032 C57BL/6
B-hTNFR2 mice(C) 112644 BALB/cCrSlcNifdc
B-hTREM1 mice 111180 C57BL/6N
B-hTREM2 mice 111176 C57BL/6N
B-hTREM2 mice(C) 111884 BALB/cCrSlcNifdc
B-hTROP2 mice 110966 C57BL/6N
B-hTYRO3 mice 111055 C57BL/6
B-hVSIG4 mice 111035 C57BL/6N
B-hVSIR mice 110049 C57BL/6N
B-hVWF mice 110907 C57BL/6
B-hα4β7 mice 111913 C57BL/6

Double Humanized Immune-checkpoint Mice

Product Product No Background
B-Tg(hLILRB1-hLILRB4) mice 110878 C57BL/6N
B-Tg(hLILRB2-hLILRB3) mice 110858 C57BL/6N
B-Tg(hSIGLEC7/hSIGLEC9) mice 121189 C57BL/6N
B-h4-1BB/h4-1BBL mice 120541 C57BL/6N
B-h4-1BB/hCD27 mice 121162 C57BL/6
B-h4-1BB/hCD40 mice 121212 C57BL/6
B-h4-1BB/hFAP mice 112772 C57BL/6
B-h4-1BB/hTIGIT mice 112328 C57BL/6
B-h4-1BB/hTNFR2 mice plus 111958 C57BL/6
B-hALB/hFcRn mice 121805 C57BL/6
B-hB2M/hHLA-G mice 111339 C57BL/6N
B-hB7-H3/hNKG2D mice 112507 C57BL/6
B-hB7-H3/hNKP46 mice 112506 C57BL/6JNifdc
B-hBTLA/hHVEM mice 121080 C57BL/6
B-hCD155/hCD112 mice 112005 C57BL/6
B-hCD16A/hNKG2D mice 112655 C57BL/6N
B-hCD16A/hNKP46 mice 112472 C57BL/6
B-hCD200/hCD200R mice 111888 C57BL/6
B-hCD226/hTIGIT mice 112759 C57BL/6
B-hCD28/hB7-H3 mice 121251 C57BL/6
B-hCD28/hCD20 mice 121253 C57BL/6
B-hCD28/hTROP2 mice 121252 C57BL/6
B-hCD3E/HLA-A2.1 mice 111858 C57BL/6
B-hCD3E/h4-1BB mice 121281 C57BL/6
B-hCD3E/h4-1BB mice(C) 112903 C57BL/6
B-hCD3E/hCD16A mice 112922 C57BL/6
B-hCD3E/hCD20 mice 121247 C57BL/6
B-hCD3E/hCD28 mice 121248 C57BL/6
B-hCD3E/hCD38 mice 111873 C57BL/6
B-hCD3E/hDLL3 mice 112939 C57BL/6
B-hCD3E/hEGFR mice 121250 C57BL/6
B-hCD3E/hEPCAM mice 112519 C57BL/6
B-hCD3E/hHER2 mice 121249 C57BL/6
B-hCD3E/hIL2RA mice 121666 C57BL/6
B-hCD3EDG/HLA-A11.1 mice 112962 C57BL/6
B-hCD3EDG/HLA-A2.1 mice 112756 C57BL/6
B-hCD3EDG/HLA-A24.2 mice 112963 C57BL/6
B-hCD3EDG/h4-1BB mice 112646 C57BL/6
B-hCD3EDG/hCD19 mice 112902 C57BL/6
B-hCD3EDG/hCD20 mice 121703 C57BL/6
B-hCD3EDG/hCD28 mice 121285 C57BL/6
B-hCD3EDG/hCD70 mice 112768 C57BL/6
B-hCD3EDG/hTROP2 mice 121633 C57BL/6
B-hCD40/hCD40L mice 121335 C57BL/6
B-hCD40/hFcRn mice 111912 C57BL/6
B-hCD73/h4-1BB mice 111877 C57BL/6
B-hCD73/hCD39 mice 111855 C57BL/6
B-hCD94/hNKG2A mice 121077 C57BL/6
B-hCSF1/hCSF1R mice 121109 C57BL/6
B-hCTLA4/h4-1BB mice 120539 C57BL/6
B-hCTLA4/hCCR8 mice 112251 C57BL/6
B-hCTLA4/hGITR mice 120962 C57BL/6
B-hCTLA4/hIL2RA mice 111851 C57BL/6
B-hCTLA4/hLAG3 mice 120529 C57BL/6
B-hCTLA4/hOX40 mice 120531 C57BL/6
B-hCTLA4/hTIGIT mice 111860 C57BL/6
B-hCTLA4/hTIM3 mice 120530 C57BL/6
B-hCTLA4/hTNFR2 mice 111843 C57BL/6
B-hFOLR1/hFOLR2 mice 111065 C57BL/6J
B-hGARP/hTGFB1 mice 112241 C57BL/6N
B-hIL21/hIL21R mice 121218 C57BL/6
B-hKIT/hKITLG mice 112090 C57BL/6
B-hMERTK/hGAS6 mice 112490 C57BL/6
B-hOX40/h4-1BB mice 120527 C57BL/6
B-hOX40/hOX40L mice 120543 C57BL/6
B-hPD-1 Plus/hGARP mice 112924 C57BL/6
B-hPD-1 plus/hIL21R mice 111847 C57BL/6
B-hPD-1 plus/hPD-L1 mice 112550 C57BL/6
B-hPD-1 plus/hTGFBR2 mice 111890 C57BL/6N
B-hPD-1/h4-1BB mice 120516 C57BL/6
B-hPD-1/hB7-H3 mice 121152 C57BL/6
B-hPD-1/hBTLA mice 120517 C57BL/6
B-hPD-1/hCD27 mice 120518 C57BL/6
B-hPD-1/hCD39 mice 121179 C57BL/6
B-hPD-1/hCD40 mice 120526 C57BL/6
B-hPD-1/hCTLA4 mice 120519 C57BL/6
B-hPD-1/hGITR mice 120528 C57BL/6
B-hPD-1/hLAG3 mice 120520 C57BL/6
B-hPD-1/hLAIR1 mice 113109 C57BL/6
B-hPD-1/hOX40 mice 120521 C57BL/6
B-hPD-1/hPD-L1 mice 120522 C57BL/6
B-hPD-1/hPD-L1 mice(C) 112489 BALB/cCrSlcNifdc
B-hPD-1/hTIGIT mice 120523 C57BL/6
B-hPD-1/hTIM3 mice 120524 C57BL/6
B-hPD-1/hTNFA mice 113143 C57BL/6
B-hPD-L1/h4-1BB mice 120535 C57BL/6
B-hPD-L1/hA2AR mice 121182 C57BL/6
B-hPD-L1/hCD27 mice 120537 C57BL/6
B-hPD-L1/hCD40 mice 120536 C57BL/6
B-hPD-L1/hCTLA4 mice 120538 C57BL/6
B-hPD-L1/hLAG3 mice 120533 C57BL/6
B-hPD-L1/hOX40 mice 120534 C57BL/6
B-hPD-L1/hPVRIG mice 112374 C57BL/6
B-hPD-L1/hTIGIT mice 120532 C57BL/6
B-hPD-L1/hTIM3 mice 120540 C57BL/6
B-hPVRIG/hTIGIT mice 121163 C57BL/6
B-hSIRPA/hCD47 mice 120525 C57BL/6
B-hSIRPA/hCD47,Il2rg KO mice 130566 C57BL/6N
B-hSIRPA/hCD47,Prkdc KO mice 130565 C57BL/6N
B-hTGFBR2/hFAP mice 113138 C57BL/6
B-hTGFBR2/hPDGFRA mice 112766 C57BL/6
B-hTIM4/hTIM1 mice 110982 C57BL/6J
B-hTLR8/hTLR7 mice 121169 C57BL/6
B-hTNFA/hTNFR2 mice 120749 C57BL/6
B-hTNFR2/hCCR8 mice 112398 C57BL/6
B-hTNFR2/hGITR mice 112551 C57BL/6
B-hTNFR2/hIL2RA mice 111846 C57BL/6
B-hTNFR2/hNKG2D mice 113110 C57BL/6
B-hTNFR2/hOX40 mice 112525 C57BL/6
B-hTNFR2/hTNFR1 mice 120802 C57BL/6
B-hTREM1/hPGLYRP1 mice 113124 C57BL/6N
B-hTREM2/hTFR1 mice 111918 C57BL/6
B-hTWEAK/hAPRIL mice 110805 C57BL/6

Triple Humanized Immune-checkpoint Mice

Product Product No Background
B-hCD3E/h4-1BB/HLA-A2.1 mice 111960 C57BL/6
B-hCD3E/hCD19/hCD20 mice 113171 C57BL/6
B-hCD3E/hCD20/hCD38 mice 112666 C57BL/6
B-hCD3E/hCD28/h4-1BB mice 112333 C57BL/6
B-hCD3E/hCD28/hCD19 mice 113092 C57BL/6
B-hCD3E/hCD28/hMUC1 mice 113093 C57BL/6
B-hCD3EDG/hCD28/hCD20 mice 112712 C57BL/6
B-hCD3EDG/hCD28/hTROP2 mice 112713 C57BL/6
B-hCD94/hNKG2A/hNKG2C mice 112445 C57BL/6
B-hCSF1/hCSF1R/hCD40 mice 112521 C57BL/6
B-hIL13/hOX40/hOX40L mice 112667 C57BL/6
B-hPD-1 plus/hPD-L1/hCD80 mice 112670 C57BL/6
B-hPD-1 plus/hPD-L1/hEGFR mice 113031 C57BL/6
B-hPD-1 plus/hPD-L1/hTROP2 mice 113032 C57BL/6
B-hPD-1/h4-1BB/h4-1BB-L mice 130567 C57BL/6
B-hPD-1/hBTLA/hHVEM mice 113166 C57BL/6
B-hPD-1/hLAG3/hTIM3 mice 130999 C57BL/6
B-hPD-1/hPD-L1,Igh-J KO mice 311126 C57BL/6
B-hPD-1/hPD-L1/HLA-A2.1 mice 113040 C57BL/6
B-hPD-1/hPD-L1/h4-1BB mice 130569 C57BL/6
B-hPD-1/hPD-L1/hB7-H3 mice 131153 C57BL/6
B-hPD-1/hPD-L1/hC5AR1 mice 131216 C57BL/6
B-hPD-1/hPD-L1/hCCR8 mice 131764 C57BL/6
B-hPD-1/hPD-L1/hCD3E mice 111923 C57BL/6
B-hPD-1/hPD-L1/hCD40 mice 131083 C57BL/6
B-hPD-1/hPD-L1/hCD73 mice 111910 C57BL/6
B-hPD-1/hPD-L1/hCTLA4 mice 130571 C57BL/6
B-hPD-1/hPD-L1/hGITR mice 131108 C57BL/6
B-hPD-1/hPD-L1/hHER2 mice 112936 C57BL/6
B-hPD-1/hPD-L1/hIL2RA mice 131078 C57BL/6
B-hPD-1/hPD-L1/hLAG3 plus mice 130572 C57BL/6
B-hPD-1/hPD-L1/hOX40 mice 311112 C57BL/6
B-hPD-1/hPD-L1/hTIGIT mice 130573 C57BL/6
B-hPD-1/hPD-L1/hTIM3 mice 130574 C57BL/6
B-hPD-1/hPD-L1/hTNFR2 mice 130849 C57BL/6
B-hPD-1/hPD-L1/hVSIR mice 131336 C57BL/6
B-hPD-1/hSIRPA/hCD47 mice 130562 C57BL/6
B-hPD-1/hTIGIT/hVEGFR2 mice 112791 C57BL/6
B-hPD-L1/hSIRPA/hCD47 mice 130561 C57BL/6
B-hSIRPA/hCD47,Prkdc/Il2rg KO mice 140739 C57BL/6
B-hSIRPA/hCD47/hCD3E mice 131590 C57BL/6
B-hTNFA/hTNFR2/hTNFR1 mice 131706 C57BL/6

Tetra Humanized Immune-checkpoint Mice

Product Product No Background
B-Tg(hLILRB2/hLILRB3/hLILRB1/hLILRB4) mice 112332 C57BL/6
B-hIL2/hIL2RA/hIL2RB/hCCR8 mice 112980 C57BL/6
B-hPD-1/hPD-L1, Tg(hLILRB2/hLILRB3) mice 111954 C57BL/6
B-hPD-1/hPD-L1/hGARP/hTGFB1 mice 112810 C57BL/6
B-hPD-1/hPD-L1/hLAG3 plus/hVSIG4 mice 113107 C57BL/6
B-hPD-1/hPD-L1/hNKG2A/hCD94 mice 111848 C57BL/6
B-hPD-1/hPD-L1/hSIRPA/hCD47 mice 140577 C57BL/6
B-hPD-1/hPD-L1/hSIRPA/hCD47,Tg(hLILRB2/hLILRB3) mice 113129 C57BL/6
B-hPD-1/hPD-L1/hTIGIT/hPVRIG mice 141337 C57BL/6
B-hSIRPA/hCD47/hCD3E/hCD28 mice 111874 C57BL/6
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