Cytokines play an important role in regulating the body’s immune, hematopoietic, nervous, and endocrine systems. Cytokine antibodies in drug development have demonstrated clinical significance in treating autoimmune and other inflammatory diseases. Backed by detailed investigation and careful design, Biocytogen presents a series of mouse models with humanized cytokines and/or cytokine receptors for preclinical evaluation of novel anti-human immunotherapies.
Humanized Cytokine Mice
| Product | Product No | Background |
|---|---|---|
| B-hALB mice | 110960 | C57BL/6J |
| B-hANGPTL4 mice | 111085 | C57BL/6N |
| B-hANGPTL8 mice | 111230 | C57BL/6N |
| B-hBAFF mice | 110830 | C57BL/6J |
| B-hBAFF/hBAFFR mice | 111921 | C57BL/6 |
| B-hBAFFR mice | 111140 | C57BL/6N |
| B-hC5/hC5AR1 mice | 121215 | C57BL/6 |
| B-hCCL2 mice | 111102 | C57BL/6N |
| B-hCCL22 mice | 110817 | C57BL/6J |
| B-hCCL3 mice | 111439 | C57BL/6N |
| B-hCCN1 mice | 111235 | C57BL/6N |
| B-hCCN2 mice | 111523 | C57BL/6N |
| B-hCCN4 mice | 111237 | C57BL/6J |
| B-hCD14 mice | 111130 | C57BL/6N |
| B-hCFD mice | 111005 | C57BL/6N |
| B-hCSF1R mice | 110035 | C57BL/6J |
| B-hCSF3 mice | 111899 | C57BL/6N |
| B-hCXCL13 mice | 111136 | C57BL/6N |
| B-hGDF15 mice | 111201 | C57BL/6N |
| B-hGFRAL mice | 111202 | C57BL/6 |
| B-hGRP mice | 111902 | C57BL/6J |
| B-hIFNB1 mice | 111210 | C57BL/6N |
| B-hIFNGR1 mice | 110804 | C57BL/6J |
| B-hIFNGR1/hIFNG mice | 120819 | C57BL/6N |
| B-hIFNGR1/hIFNG/hIFNGR2 mice | 130949 | C57BL/6 |
| B-hIFNGR2 mice | 110803 | C57BL/6J |
| B-hIGFBP2 mice | 110987 | C57BL/6J |
| B-hIL10 mice | 110060 | C57BL/6J |
| B-hIL10/hIL10RA mice | 120750 | C57BL/6 |
| B-hIL10RA mice | 110083 | C57BL/6J |
| B-hIL10RB mice | 110773 | C57BL/6J |
| B-hIL11 mice | 110079 | C57BL/6J |
| B-hIL11/hIL11RA mice | 111865 | C57BL/6 |
| B-hIL11RA mice | 110879 | C57BL/6J |
| B-hIL12A/hIL12B/hIL12RB1/hIL12RB2 mice | 140575 | C57BL/6J |
| B-hIL13 mice | 110058 | C57BL/6J |
| B-hIL15/hIL15RA mice | 121217 | C57BL/6 |
| B-hIL15RA mice | 110112 | C57BL/6J |
| B-hIL17A Mice | 110053 | C57BL/6J |
| B-hIL17A/hIL17F mice | 120554 | C57BL/6N |
| B-hIL17RA mice | 110054 | C57BL/6J |
| B-hIL17RB mice | 110090 | C57BL/6J |
| B-hIL18 mice | 111276 | C57BL/6N |
| B-hIL19 mice | 111597 | C57BL/6N |
| B-hIL1A mice | 110073 | C57BL/6J |
| B-hIL1B mice | 110075 | C57BL/6J |
| B-hIL1RAcP mice | 110072 | C57BL/6J |
| B-hIL2 mice | 110085 | C57BL/6J |
| B-hIL2/hIL2RA/hIL2RB mice | 131076 | C57BL/6 |
| B-hIL21R mice | 110766 | C57BL/6J |
| B-hIL22/hIL22RA1 mice | 121704 | C57BL/6 |
| B-hIL22RA1/hIL10RB mice | 112331 | C57BL/6 |
| B-hIL23A/hIL12B mice | 120553 | C57BL/6 |
| B-hIL27 mice | 110763 | C57BL/6J |
| B-hIL27/hIL27RA mice | 121566 | C57BL/6 |
| B-hIL27RA mice | 110765 | C57BL/6J |
| B-hIL2RA mice | 110066 | C57BL/6J |
| B-hIL2RB mice | 110737 | C57BL/6J |
| B-hIL2RB/hIL15 mice | 111945 | C57BL/6 |
| B-hIL2RB/hIL2RG mice | 111850 | C57BL/6 |
| B-hIL2RB/hIL2RG/hIL15/hIL15RA mice | 111866 | C57BL/6 |
| B-hIL2RG mice | 110087 | C57BL/6N |
| B-hIL3 mice | 110080 | C57BL/6J |
| B-hIL31/hIL31RA mice | 120745 | C57BL/6 |
| B-hIL33 mice | 110055 | C57BL/6J |
| B-hIL33/hTSLP/hTSLPR mice | 111867 | C57BL/6 |
| B-hIL36A mice | 110092 | C57BL/6N |
| B-hIL36R mice | 110084 | C57BL/6J |
| B-hIL36R/hIL1RACP mice | 112383 | C57BL/6 |
| B-hIL4 mice | 110064 | C57BL/6 |
| B-hIL4/hIL4RA mice | 120551 | C57BL/6 |
| B-hIL4/hIL4RA/hIL13 mice | 131037 | C57BL/6N |
| B-hIL6/hIL6R mice | 120557 | C57BL/6 |
| B-hIL7R mice | 110082 | C57BL/6J |
| B-hIL9R mice | 110761 | C57BL/6J |
| B-hLTA/hTNFA/hLTB mice | 130769 | C57BL/6J |
| B-hMIF mice | 111047 | C57BL/6N |
| B-hPAI1 mice | 111119 | C57BL/6N |
| B-hPCSK9 mice | 110928 | C57BL/6J |
| B-hPD-1/hPCSK9 mice | 111861 | C57BL/6 |
| B-hPD-1/hPD-L1/hCSF1/hCSF1R mice | 111854 | C57BL/6 |
| B-hPD-1/hPD-L1/hIL1B mice | 131619 | C57BL/6 |
| B-hRSPO1 mice | 110900 | C57BL/6N |
| B-hS100A9 mice | 111224 | C57BL/6N |
| B-hSELE/hSELL mice | 121056 | C57BL/6J |
| B-hSORT1 mice | 111158 | C57BL/6N |
| B-hSOST mice | 110111 | C57BL/6J |
| B-hSPP1 mice | 111087 | C57BL/6N |
| B-hTDGF1 mice | 111225 | C57BL/6N |
| B-hTEK mice | 111106 | C57BL/6J |
| B-hTGM2 mice | 111028 | C57BL/6J |
| B-hTNFA mice | 110002 | C57BL/6J |
| B-hTNFA/hIL17A mice | 120548 | C57BL/6 |
| B-hTNFA/hTNFR2 mice | 120749 | C57BL/6 |
| B-hTNFR2 mice | 110032 | C57BL/6J |
| B-hTSLP mice | 110834 | C57BL/6 |
| B-hTSLP/hTSLPR mice | 121269 | C57BL/6 |
| B-hTSLP/hTSLPR/hIL7R mice | 111951 | C57BL/6 |
| B-hVEGFA mice | 110822 | C57BL/6J |
