Cytokines play an important role in regulating the body’s immune, hematopoietic, nervous, and endocrine systems. Cytokine antibodies in drug development have demonstrated clinical significance in treating autoimmune and other inflammatory diseases. Backed by detailed investigation and careful design, Biocytogen presents a series of mouse models with humanized cytokines and/or cytokine receptors for preclinical evaluation of novel anti-human immunotherapies.
Humanized Cytokine Mice
| Product | Product No | Background |
|---|---|---|
| B-Tg(hIFNG/hIL26) mice | 131596 | C57BL/6N |
| B-Tg(hIL8) mice | 110832 | C57BL/6N |
| B-hADIPOQ mice | 111594 | C57BL/6 |
| B-hADM mice | 111150 | C57BL/6N |
| B-hAFP mice | 111622 | C57BL/6N |
| B-hALB mice | 110960 | C57BL/6J |
| B-hANG2 mice | 112028 | C57BL/6 |
| B-hANGPTL3 mice | 112224 | C57BL/6 |
| B-hANGPTL3 mice plus | 112523 | C57BL/6N |
| B-hANGPTL4 mice | 111085 | C57BL/6N |
| B-hANGPTL4 mice plus | 112746 | C57BL/6JNifdc |
| B-hANGPTL8 mice | 111230 | C57BL/6N |
| B-hBAFF mice | 110830 | C57BL/6 |
| B-hBAFF/hBAFFR mice | 111921 | C57BL/6 |
| B-hBAFFR mice | 111140 | C57BL/6N |
| B-hC3 mice | 112467 | C57BL/6N |
| B-hC5/hC5AR1 mice | 121215 | C57BL/6 |
| B-hCCL11 mice | 111404 | C57BL/6N |
| B-hCCL2 mice | 111102 | C57BL/6N |
| B-hCCL20 mice | 110854 | C57BL/6N |
| B-hCCL22 mice | 110817 | C57BL/6 |
| B-hCCL24 mice | 111396 | C57BL/6N |
| B-hCCL3 mice | 111439 | C57BL/6N |
| B-hCCL4 mice | 111440 | C57BL/6JNifdc |
| B-hCCL5 mice | 111192 | C57BL/6N |
| B-hCCL8 mice | 111400 | C57BL/6N |
| B-hCCN1 mice | 111235 | C57BL/6N |
| B-hCCN2 mice | 111523 | C57BL/6N |
| B-hCCN4 mice | 111237 | C57BL/6 |
| B-hCD14 mice | 111130 | C57BL/6N |
| B-hCD59 mice | 111427 | C57BL/6 |
| B-hCD5L mice | 112516 | C57BL/6JNifdc |
| B-hCDH17 mice | 111593 | C57BL/6 |
| B-hCETP mice | 111443 | C57BL/6 |
| B-hCFB mice | 111006 | C57BL/6N |
| B-hCFB/hC5 mice | 113233 | C57BL/6 |
| B-hCFD mice | 111005 | C57BL/6N |
| B-hCSF1R mice | 110035 | C57BL/6 |
| B-hCSF2RB mice | 110735 | C57BL/6 |
| B-hCSF3 mice | 111899 | C57BL/6N |
| B-hCXCL1 mice | 111395 | C57BL/6N |
| B-hCXCL10 mice | 111354 | C57BL/6N |
| B-hCXCL13 mice | 111136 | C57BL/6N |
| B-hCXCL16 mice | 111193 | C57BL/6N |
| B-hCXCL3 mice | 112600 | C57BL/6N |
| B-hCXCL7 mice | 112404 | C57BL/6N |
| B-hCXCL7/hCXCL4 mice | 112063 | C57BL/6N |
| B-hDKK1 mice | 111277 | C57BL/6N |
| B-hEPO mice | 112458 | C57BL/6N |
| B-hF3 mice | 110967 | C57BL/6N |
| B-hFAP/hIFNGR1/hIFNG/hIFNGR2 mice | 113111 | C57BL/6 |
| B-hFCER1A mice | 111090 | C57BL/6N |
| B-hFGF21 mice | 112156 | C57BL/6N |
| B-hFGG mice | 112917 | C57BL/6N |
| B-hGDF15 mice | 111201 | C57BL/6N |
| B-hGDF8 mice | 112413 | C57BL/6N |
| B-hGEP mice | 112346 | C57BL/6N |
| B-hGFRAL mice | 111202 | C57BL/6 |
| B-hGHRL mice | 111092 | C57BL/6N |
| B-hGRP mice | 111902 | C57BL/6 |
| B-hHAMP mice | 111019 | C57BL/6N |
| B-hICOS mice | 112105 | C57BL/6 |
| B-hIFNAR1/hIFNAR2 mice | 112650 | C57BL/6N |
| B-hIFNAR2 mice | 112400 | C57BL/6N |
| B-hIFNB1 mice | 111210 | C57BL/6N |
| B-hIFNGR1 mice | 110804 | C57BL/6 |
| B-hIFNGR1/hIFNG mice | 120819 | C57BL/6 |
| B-hIFNGR1/hIFNG/hIFNGR2 mice | 130949 | C57BL/6 |
| B-hIFNGR2 mice | 110803 | C57BL/6 |
| B-hIGF1R mice | 111274 | C57BL/6 |
| B-hIGF2R mice | 110986 | C57BL/6 |
| B-hIGFBP2 mice | 110987 | C57BL/6J |
| B-hIGFBP7 mice | 111976 | C57BL/6N |
| B-hIL10 mice | 110060 | C57BL/6 |
| B-hIL10/hIL10RA mice | 120750 | C57BL/6 |
| B-hIL10/hIL10RA/hIL10RB mice | 112664 | C57BL/6 |
| B-hIL10RA mice | 110083 | C57BL/6 |
| B-hIL10RA/hIL10RB mice | 111871 | C57BL/6 |
| B-hIL10RA/hIL2RG mice | 111870 | C57BL/6 |
| B-hIL10RB mice | 110773 | C57BL/6 |
| B-hIL11 mice | 110079 | C57BL/6 |
| B-hIL11/hIL11RA mice | 111865 | C57BL/6 |
| B-hIL11RA mice | 110879 | C57BL/6 |
| B-hIL12RB1/hIL12RB2 mice ad | 112881 | C57BL/6 |
| B-hIL13 mice | 110058 | C57BL/6 |
| B-hIL13RA1 mice | 111717 | C57BL/6 |
| B-hIL15/hIL15RA mice | 121217 | C57BL/6 |
| B-hIL15RA mice | 110112 | C57BL/6 |
| B-hIL17A/hIL17F mice | 120554 | C57BL/6 |
| B-hIL17B mice | 110089 | C57BL/6 |
| B-hIL17RA mice | 110054 | C57BL/6J |
| B-hIL17RA/hIL17RB mice | 112896 | C57BL/6 |
| B-hIL17RA/hIL17RB/hIL25 mice | 113268 | C57BL/6 |
| B-hIL17RA/hIL17RC mice | 120555 | C57BL/6 |
| B-hIL17RB mice | 110090 | C57BL/6J |
| B-hIL17RB/hIL25 mice | 120560 | C57BL/6 |
| B-hIL18 mice | 111276 | C57BL/6N |
| B-hIL18BP mice | 112360 | C57BL/6 |
| B-hIL19 mice | 111597 | C57BL/6N |
| B-hIL1B mice | 110075 | C57BL/6 |
| B-hIL1RAcP mice | 110072 | C57BL/6J |
| B-hIL2 mice | 110085 | C57BL/6 |
| B-hIL2/hIL2RA/hIL2RB mice | 131076 | C57BL/6 |
| B-hIL2/hIL2RA/hIL2RB/hIL2RG mice | 112748 | C57BL/6 |
| B-hIL20 mice | 111995 | C57BL/6N |
| B-hIL21R mice | 110766 | C57BL/6 |
| B-hIL21R/hIL2RG mice | 112925 | C57BL/6 |
| B-hIL22/hIL22RA1 mice | 121704 | C57BL/6 |
| B-hIL22/hIL22RA1/hIL10RB mice | 113344 | C57BL/6 |
| B-hIL22RA1/hIL10RB mice | 112331 | C57BL/6 |
| B-hIL23A/hIL12B mice | 120553 | C57BL/6 |
| B-hIL26 mice | 112582 | C57BL/6 |
| B-hIL27 mice | 110763 | C57BL/6 |
| B-hIL27/hIL27RA mice | 121566 | C57BL/6 |
| B-hIL27RA mice | 110765 | C57BL/6J |
| B-hIL2RA mice | 110066 | C57BL/6 |
| B-hIL2RB mice | 110737 | C57BL/6 |
| B-hIL2RB/hIL15 mice | 111945 | C57BL/6 |
| B-hIL2RB/hIL2RG mice | 111850 | C57BL/6 |
| B-hIL2RB/hIL2RG/hIL15/hIL15RA mice | 111866 | C57BL/6 |
| B-hIL2RG mice | 110087 | C57BL/6N |
| B-hIL3 mice | 110080 | C57BL/6 |
| B-hIL31/hIL31RA/hOSM/hOSMR mice | 112647 | C57BL/6 |
| B-hIL31/hIL31RA/hOSMR mice | 130746 | C57BL/6 |
| B-hIL31/hIL31RA/hOSMR/hIL4/hIL4RA mice | 112908 | C57BL/6 |
| B-hIL33 mice | 110055 | C57BL/6 |
| B-hIL33/hTSLP/hTSLPR mice | 111867 | C57BL/6 |
| B-hIL33/hTSLP/hTSLPR mice plus | 112935 | C57BL/6 |
| B-hIL36A mice | 110092 | C57BL/6N |
| B-hIL36R mice | 110084 | C57BL/6J |
| B-hIL36R/hIL1RACP mice | 112383 | C57BL/6 |
| B-hIL4/hIL4RA mice | 120551 | C57BL/6 |
| B-hIL4/hIL4RA mice(C.B6) | 111889 | BALB/cCrSlcNifdc.C57BL/6JNifdc |
| B-hIL4/hIL4RA/hIL13 mice | 131037 | C57BL/6 |
| B-hIL4/hIL4RA/hIL13/hIL13RA1 mice | 112812 | C57BL/6 |
| B-hIL4/hIL4RA/hTSLP/hTSLPR mice | 112954 | C57BL/6 |
| B-hIL4/hIL4RA/hTSLP/hTSLPR plus mice | 112846 | C57BL/6 |
| B-hIL5 mice | 110071 | C57BL/6J |
| B-hIL5/hIL5RA mice | 111932 | C57BL/6N |
| B-hIL6/hIL6R mice | 120557 | C57BL/6 |
| B-hIL6ST mice | 111200 | C57BL/6 |
| B-hIL7R mice | 110082 | C57BL/6 |
| B-hIL9 mice | 110760 | C57BL/6 |
| B-hIL9R mice | 110761 | C57BL/6J |
| B-hINHBE mice | 112773 | C57BL/6JNifdc |
| B-hIgE/hFCER1A mice | 111891 | C57BL/6N |
| B-hKLK2/hKLK3 mice | 112233 | C57BL/6 |
| B-hLAIR1 mice | 111660 | C57BL/6N |
| B-hLIF mice | 111199 | C57BL/6N |
| B-hLPA mice | 112723 | C57BL/6 |
| B-hLPA mice plus | 112845 | C57BL/6 |
| B-hLTA/hTNFA/hLTB mice | 130769 | C57BL/6J |
| B-hLTA/hTNFA/hLTB/hTNFR2/hTNFR1/hLTBR mice | 113337 | C57BL/6 |
| B-hLYPD3 mice | 111661 | C57BL/6 |
| B-hMAG mice | 111033 | C57BL/6N |
| B-hMIF mice | 111047 | C57BL/6N |
| B-hOSM/hOSMR mice | 121329 | C57BL/6 |
| B-hPAI1 mice | 111119 | C57BL/6N |
| B-hPCSK9 mice | 110928 | C57BL/6 |
| B-hPCSK9 mice plus | 112751 | C57BL/6 |
| B-hPD-1/hPCSK9 mice | 111861 | C57BL/6 |
| B-hPD-1/hPD-L1/hCSF1/hCSF1R mice | 111854 | C57BL/6 |
| B-hPD-1/hPD-L1/hIL1B mice | 131619 | C57BL/6 |
| B-hPD-1/hPD-L1/hVEGFA mice | 112706 | C57BL/6 |
| B-hPD-1/hPD-L1/hVEGFR2 mice | 112494 | C57BL/6 |
| B-hPDGFD mice | 111316 | C57BL/6N |
| B-hPGF mice | 111040 | C57BL/6 |
| B-hPTHRP mice | 111017 | C57BL/6N |
| B-hRNASE4 mice | 112595 | C57BL/6 |
| B-hRSPO1 mice | 110900 | C57BL/6N |
| B-hRSPO3 mice | 110883 | C57BL/6 |
| B-hS100A9 mice | 111224 | C57BL/6N |
| B-hS100A9/hS100A8 mice | 121444 | C57BL/6N |
| B-hSELE/hSELL mice | 121056 | C57BL/6 |
| B-hSORT1 mice plus | 112493 | C57BL/6N |
| B-hSOST mice | 110111 | C57BL/6 |
| B-hSPP1 mice | 111087 | C57BL/6N |
| B-hTDGF1 mice | 111225 | C57BL/6N |
| B-hTEK mice | 111106 | C57BL/6 |
| B-hTFF1 mice | 112542 | C57BL/6N |
| B-hTGM2 mice | 111028 | C57BL/6 |
| B-hTNFA mice | 110002 | C57BL/6 |
| B-hTNFA/hIL17A mice | 120548 | C57BL/6 |
| B-hTNFA/hTNFR2 mice | 120749 | C57BL/6 |
| B-hTNFR2 mice | 110032 | C57BL/6 |
| B-hTNFR2/hTNFR1/hLTBR mice | 140801 | C57BL/6 |
| B-hTSLP/hTSLPR mice | 121269 | C57BL/6 |
| B-hTSLP/hTSLPR mice plus | 112744 | C57BL/6 |
| B-hTSLP/hTSLPR mice(C) | 112923 | BALB/cCrSlcNifdc |
| B-hTWEAK/hAPRIL mice | 110805 | C57BL/6 |
| B-hVEGFA mice | 110822 | C57BL/6 |
| B-hVEGFA/hANG2 mice | 113125 | C57BL/6 |
| B-hVEGFR1 mice | 110981 | C57BL/6J |
| B-hWNT16 mice | 111010 | C57BL/6 |
| B-hWNT3A mice | 111021 | C57BL/6J |
