Poster Category

AACR 2022: YH012, a Novel Bispecific Anti-HER2 and TROP2 Antibody-Drug Conjugate, Exhibits Potent Antitumor Efficacy

Conclusions YH012 is a novel bispecific HER2/TROP2 antibody-drug conjugate (BsAb-ADC) developed using the RenLiteTM platform. The TAAs HER2 and TROP2 are highly co-expressed in a…

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AACR 2022: Generation of TCR-like fully human antibodies against HLA-antigen-peptide complexes using HLA transgenic RenMice

Conclusions We describe an HLA transgenic mouse that acquires fully human TCR mimic antibodies through a proprietary immunization procedure. Beacon on-chips screening and high-throughput binding…

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AACR 2022: 1C3, a Novel Non-blocking Anti-human TNFR2 Antibody Generated From RenMice, Exhibits Promising Anti-tumor Activity and Safety in Syngeneic Tumor Models in Humanized TNFR2 Mice

Conclusions An anti-TNFR2 antibody, 1C3, was obtained via unbiased screening by detecting efficacy using humanized mice. 1C3 binds to the CRD3 AND CRD4 domains of…

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AACR 2022: Advancing the Development of CD16A-Based Bispecific Antibodies in Humanized CD16A Mouse Models

Conclusions Human CD16A expression was confirmed in homozygous B-hCD16A mice by RT-PCR and flow cytometry. Similar proportions of splenic immune cells were observed between humanized…

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AACR 2022: Generation of a Novel Humanized TLR8 Mouse Model for the Evaluation of Human TLR8 Agonists and Antibody-Conjugated TLR8 Agonists

Conclusions mRNA expression analysis: Mouse Tlr8 mRNA was detectable in wild-type C57BL/6 mice (+/+). Human TLR8 mRNA was detectable only in heterozygote B-hTLR8 but not…

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AACR 2022: A Humanized Mouse Model of the Promising Immune Checkpoint Molecule B7-H4

Conclusions As a negative regulator of T cell responses that is highly expressed in a range of carcinoma types, B7-H4 has emerged in recent years…

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AACR 2022: Functional Analysis of Anti-TSLP Antibodies Using Humanized B-hTSLP/hTSLPR Mice

Conclusions • TSLP and TSLPR protein expression analysis: Human TSLP and TSLPR protein was exclusively detected in humanized B-hTSLP/hTSLPR mice compared to wild-type mice by…

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AACR 2022: Humanized PVRIG Mice: A Novel Tool for Evaluating Anti-PVRIG Immunotherapies

Conclusions mRNA gene expression analysis by RT-PCR: Murine Pvrig mRNA was detected in splenocytes isolated from wild-type C57BL/6 (+/+) mice, while human PVRIG mRNA was…

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AACR 2022: Generation and Validation of Humanized GARP Mice for Testing Novel Anti-Human GARP Antibodies

Conclusions We have generated a humanized mouse model expressing GARP in place of the murine counterpart. mRNA and protein expression of human GARP indicates successful…

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AACR 2022: Evaluating In Vivo Efficacy of Bi-Functional Fusion Protein Anti-PD-1-IL21 in Humanized B-hIL21R Mice and B-hPD-1/hIL21R Mice

Conclusions mRNA expression analysis: Murine Il21r mRNA was detected in splenocytes isolated from wild-type mice, while human IL21R mRNA was detected only in humanized B-hIL21R…

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