Cre Mouse/Rat Models

Researchers use gene-edited mouse models to study gene expression, investigate genetic diseases, conduct preclinical drug efficacy tests and more. In many studies, a mouse model expresses a gene mutation throughout its development and life, necessitating an inducible disease model when researchers need more control over the mouse’s gene expression.

Mouse models that provide this level of control are called conditional mouse models, of which one of the most effective is the Cre/Loxp mouse. Cre mice lines express Cre recombinase under the control of certain tissue specific gene promoter, i.e. Cre mouse line provides the tissue specificity of gene editing. If CreERT2 instead of Cre is used, then the DNA recombinase activity is induced by Tamoxifen, so that the Cre/Loxp mouse model will be conditional and inducible. The LoxP mouse line has two loxP elements flanking the entire or part of the gene of interest, giving the loxP mouse defined gene(s) to be edited.

The Cre-Lox system is an efficient method for producing conditional mouse models. At Biocytogen, we provide custom Cre-Lox mouse models for use in academic and pharmaceutical research. We can design a Cre mouse model, conduct research and deliver results in as little as nine months. Fill out a form or contact us today to learn more.

Cre Mouse Models List

Product Product No Application Fields
B-ALB-CreERT2 Mice 110137 Alb promoter-driven inducible Cre mouse model (liver)
B-CAG-iCreERT2 mice 110147 Cre ubiquitous expression in mice
B-CAG-tdTomato cKI Mice 110148 Cre-induced tdTomato expression for Cre expression profile detection
B-CD150-iCreERT2 Mice 110142 CD150 promoter-driven inducible Cre mouse model (Thymic, T cells and macrophages)
B-Cam1(Mcpt5)-iCre mice 110138
B-Cdh5-iCreERT2 mice 110140 Cdh5 promoter-driven inducible Cre mouse model ( lung adult, subcutaneous fat pad adult)
B-Col10a1-iCre Mice 110122 Col10a1 promoter-driven Cre mouse model (mature hypertrophic chondrocyte)
B-Col2a1-iCre Mice 110123 Col2 promoter-driven Cre mouse model (type II collencyte)
B-Dcp2-iCreERT2 mice 110138 Dcp2 promoter-driven inducible Cre mouse model. (Macrophages)
B-Dmp1-iCre Mice 110124 Dmp1 promoter-driven Cre mouse model (skeleton)
B-Gfap-iCre mice 110155 Gfappromoter-driven Cre mouse model. (Astroglia)
B-Grpr-iCre Mice 110125 Grpr promoter-driven Cre mouse model (digestive system, nervous system)
B-Ins1-iCreERT2 Mice 110126 Ins1 promoter-driven inducible Cre mouse model (pancreas isletbeta cell)
B-Myh6-iCreERT2 mice 110127 Myh6 promoter-driven inducible Cre mouse model (Heart)
B-Ncr1 (Nkp46)-iCre Mice 110127 Ncr1 promoter-driven Cre mouse model (NK cell)
B-Oxr1-iCreERT2 Mice 110128 Oxr1 promoter-driven inducible Cre mouse model (frontal lobe adult, cerebellum adult and 24 other tissues)
B-Pdgfrb-iCre Mice 110129 Pdgfrb promoter-driven inducible Cre mouse model (parietal cell of multiple organs, such as skin, intestinal tract, kidney, lung and plexus vasculosus around central nervous system)
B-Prrx1-iCre Mice 110130 Prrx1 promoter-driven Cre mouse model (mesenchyme)
B-Sp7 (Osx)-iCre Mice 110131 Sp7 promoter-driven Cre mouse model (skeleton)
B-Syn1-iCre Mice B-CM-005 Syn1promoter-driven inducible Cre mouse model (brain)
B-Tcf21-iCreERT2 mice 110141 Tcf21 promoter-driven inducible Cre mouse model (bladder, lung)
B-Tex264-iCre-EGFP mice 110136 Tex264 promoter-driven Cre mouse model(Ubiquitous expression in adrenal,kidney and 28 other tissues)
B-Tnfrsf11a (RANK)-iCre Mice B-EM-009 Tnfrsf11a promoter-driven Cre mouse model (lymph gland formation and osteoclast differentiation system)
B-Ucp1-iCre Mice 110134 UCP1 promoter-driven Cre mouse model (mitochondria, brown fat)
B-Zeb1-iCreERT2 Mice 110135 Zeb1 promoter-driven inducible Cre mouse model (tunica media of artery and myocardial cell)

Cre Rat Models List

Product Product No Application Fields
B-3XGFP cKI Rats B-CR-017 Cre-induced GFP expression, for Cre expression profile detection
B-ALB-CreERT2 Rats B-CR-019 Alb promoter-driven inducible Cre rat model (Liver)
B-Avp-iCre rats 210500 Avp promoter-driven Cre rat model(Hypothalamus)
B-CAG-GFP cKI rats B-CR-017
B-Camk2a-Cre Rats B-CR-001 Camk2a promoter-driven Cre rat model (Cortex, frontal lobe)
B-Drd1-Cre Rats B-CR-002 Drd1 promoter-driven Cre rat model (nucleus accumbens, dorsal striatum)
B-Drd2-Cre Rats B-CR-003 Drd2 promoter-driven Cre rat model (nucleus accumbens, dorsal striatum, pituitary)
B-Kit-CreERT2 Rats B-CR-004 Kit promoter-driven inducible Cre rat model (lung, cerebellum)
B-Myh6-CreERT2 Rats B-CR-018 Myh6 promoter-driven inducible Cre rat model (Heart)
B-Nphs2 (podocin)-CreERT2 Rats B-CR-005 Nphs2 promoter-driven inducible Cre rat model (Kidney)
B-Oxt-iCre rats 210501 Oxt promoter-driven Cre rat model (hypothalamus;)
B-Slc6a2-Cre Rats B-CR-007 Slc6a2 promoter-driven Cre rat model (Noradrenergic neuron)
B-Slc6a3 (Dat1)-Cre Rats B-CR-008 Slc6a3 promoter-driven Cre rat model (Dopaminergic neurons)
B-Sncg (Synuclein,Gamma)-Cre Rats B-CR-009 Sncg promoter-driven Cre rat model (dorsal striatum)
B-Tdtomato cKI Rats B-CR-011 Cre-induced GFP expression, for Cre expression profile detection

Cre Rat Models List

Product Product No Application Fields
B-Tg(Myh6-CreERT2) rats 210514 Myh6 promoter-driven Cre rat model (Heart)
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