Researchers use gene-edited mouse models to study gene expression, investigate genetic diseases, conduct preclinical drug efficacy tests and more. In many studies, a mouse model expresses a gene mutation throughout its development and life, necessitating an inducible disease mouse model when researchers need more control over gene expression.

Mouse models that provide this level of control are called conditional mouse models, of which one of the most effective is the Cre/Loxp mouse. Cre mice express Cre recombinase under the control of a tissue specific gene promoter, i.e. Cre mouse lines provide the tissue specificity of gene editing. If CreERT2 instead of Cre is used, then the DNA recombinase activity is induced by Tamoxifen, so that the Cre/Loxp mouse model will be conditional and inducible. The LoxP mouse line has two loxP elements flanking the entire or part of the gene of interest, giving the loxP mouse defined gene(s) to be edited.

The Cre-Lox system is an efficient method for producing conditional mouse models. At Biocytogen, we provide custom Cre-Lox mouse models for use in academic and pharmaceutical research. We can design a Cre mouse model, conduct research and deliver results in as little as nine months. Fill out a form or contact us today to learn more.

Cre Mouse Models List

Product Product No Background Application
B-Alb-iCreERT2 mice 110137 C57BL/6 B-Alb-iCreERT2 mice expressing icreERT2 under the control of the Alb promoter allow efficient Tamoxifen-dependent recombination of floxed DNA selectively in hepatocytes.
B-CAG-iCreERT2 mice 110147 C57BL/6 Function research of genes, Systemic knockout of lethal target genes in embryos
B-Camk2a-iCre-EGFP mice 110780 C57BL/6 • Function research of genes • Function research of synaptic plasticity and Long Term Potentiation (LTP) in hippocampal networks
B-Cdh5-iCreERT2 mice 110140 C57BL/6N Cdh5 promoter-driven inducible Cre mouse model ( lung adult, subcutaneous fat pad adult)
B-Col10a1-iCre mice 110122 C57BL/6
B-Cx3cr1-iCreERT2-EGFP mice 110779 C57BL/6N
  • Function research of genes
  • Function research of microglial cells and other Cx3cr1-expressing immune cells
B-Dmp1-iCre mice 110124 C57BL/6
B-Epor-EGFP-iCre mice 110880 C57BL/6N

Function research of genes,

Function research of erythrocytes

B-Foxc2-iCreERT2 mice 110951 C57BL/6
B-Gfap-iCre mice 110144 C57BL/6 Gfap promoter-driven Cre mouse model. (Astroglia)
B-Grpr-iCre Mice 110125 C57BL/6 Grpr promoter-driven Cre mouse model (digestive system, nervous system)
B-Htr2c-iCre mice 110139 C57BL/6
  • Function research of genes
  • This Htr2ciCre model is an efficient tool to study the various gene functions when crossed with mice with different loxP site-flanked genes of interest.
B-Lyz2-iCre-EGFP mice 110782 C57BL/6 B-Lyz2-iCre-EGFP mice may be useful for Cre-loxP studies of the myeloid cell lineage and the innate immune response.
B-Mcpt5-iCre mice 110138 C57BL/6 B-Mcpt5-iCre mice may be useful for generating mast cell-specific conditional mutations.
B-Nkp46-iCre mice 110127 C57BL/6 Ncr1 promoter-driven Cre mouse model (NK cell)
B-Pdgfrb-iCre Mice 110129 C57BL/6 Pdgfrb promoter-driven inducible Cre mouse model (parietal cell of multiple organs, such as skin, intestinal tract, kidney, lung and plexus vasculosus around central nervous system)
B-Pdx-iCre mice 120751 C57BL/6 B-Pdx-iCre mice may be useful for generating pancreas-specific conditional mutations.
B-Pgr-iCre mice 110155 C57BL/6N • Function research of genes • Function research of reproductive system
B-Prrx1-iCre Mice 110130 C57BL/6 Prrx1 promoter-driven Cre mouse model (mesenchyme)
B-Rank-iCre mice 110133 C57BL/6
B-Sp7-iCre mice 110131 C57BL/6 Function research of genes

This Sp7iCre model is an efficient tool to study various gene functions when crossed with mice with different loxP site-flanked genes of interest, especially in studies of bone development, osteoblast lineage, and Hedgehog/Wnt signaling..

B-Tagln-iCre mice 110146 C57BL/6
  • Function research of genes
  • Function research of smooth muscle cell
B-Tcf21-iCreERT2 mice 110141 C57BL/6 Tcf21 promoter-driven inducible Cre mouse model (bladder, lung)
B-Tie2-iCreERT2-EGFP mice 110781 C57BL/6
B-Ucp1-iCre Mice 110134 C57BL/6 UCP1 promoter-driven Cre mouse model (mitochondria, brown fat)

Cre Rat Models List

Product Product No Background Application
B-CAG-iCre rats 211350 SD
  • Function research of genes
  • This CAGiCre model is an efficient tool to study various gene functions when crossed with rats with different loxP site-flanked genes of interest and non-embryonic death.
B-Drd1-Cre rats 210487 SD
B-Drd2-Cre Rats 210488 SD
  • Function research of genes
  • This Drd2Cre model is an efficient tool to study various gene functions when crossed with rats with different loxP site-flanked genes of interest, especially in studies of D2 dopamine receptor subtype-expressing neurons, and may be useful for studying dopamine-sensitive behaviors such as addiction.
B-Oxt-iCre rats 210501 SD Oxt promoter-driven Cre rat model (hypothalamus;)
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