Researchers use gene-edited mouse models to study gene expression, investigate genetic diseases, conduct preclinical drug efficacy tests and more. In many studies, a mouse model expresses a gene mutation throughout its development and life, necessitating an inducible disease mouse model when researchers need more control over gene expression.

Mouse models that provide this level of control are called conditional mouse models, of which one of the most effective is the Cre/Loxp mouse. Cre mice express Cre recombinase under the control of a tissue specific gene promoter, i.e. Cre mouse lines provide the tissue specificity of gene editing. If CreERT2 instead of Cre is used, then the DNA recombinase activity is induced by Tamoxifen, so that the Cre/Loxp mouse model will be conditional and inducible. The LoxP mouse line has two loxP elements flanking the entire or part of the gene of interest, giving the loxP mouse defined gene(s) to be edited.

The Cre-Lox system is an efficient method for producing conditional mouse models. At Biocytogen, we provide custom Cre-Lox mouse models for use in academic and pharmaceutical research. We can design a Cre mouse model, conduct research and deliver results in as little as nine months. Fill out a form or contact us today to learn more.

Cre Mouse Models List

Product Product No Background Application Application Fields
B-Alb-iCreERT2 mice 110137 C57BL/6
B-CAG-iCreERT2 mice 110147 Function research of genes, Systemic knockout of lethal target genes in embryos
B-CAG-tdTomato cKI mice 110148 Cre-induced tdTomato expression for Cre expression profile detection
B-Camk2a-iCre-EGFP mice 110780 • Function research of genes • Function research of synaptic plasticity and Long Term Potentiation (LTP) in hippocampal networks
B-Cdh5-iCreERT2 mice 110140 Cdh5 promoter-driven inducible Cre mouse model ( lung adult, subcutaneous fat pad adult)
B-Col10a1-iCre mice 110122 C57BL/6
B-Cx3cr1-iCreERT2-EGFP mice 110779
  • Function research of genes
  • Function research of microglial cells and other Cx3cr1-expressing immune cells
B-Dmp1-iCre mice 110124 C57BL/6
B-Epor-EGFP-iCre mice 110880

Function research of genes,

Function research of erythrocytes

B-Foxc2-iCreERT2 mice 110951 C57BL/6
B-Foxp3-EGFP-Luc mice 112682 Regulatory T cell visualizing and ablation
B-Gfap-iCre mice 110144 Gfap promoter-driven Cre mouse model. (Astroglia)
B-Grpr-iCre Mice 110125 Grpr promoter-driven Cre mouse model (digestive system, nervous system)
B-Htr2c-iCre mice 110139
  • Function research of genes
  • This Htr2ciCre model is an efficient tool to study the various gene functions when crossed with mice with different loxP site-flanked genes of interest.
B-Lyz2-iCre-EGFP mice 110782 C57BL/6
B-Mcpt5-iCre mice 110138 C57BL/6
B-Nkp46-iCre mice 110127 Ncr1 promoter-driven Cre mouse model (NK cell)
B-Pdgfrb-iCre Mice 110129 Pdgfrb promoter-driven inducible Cre mouse model (parietal cell of multiple organs, such as skin, intestinal tract, kidney, lung and plexus vasculosus around central nervous system)
B-Pdx-iCre mice 120751 C57BL/6 B-Pdx-iCre mice may be useful for generating pancreas-specific conditional mutations.
B-Pgr-iCre mice 110155 • Function research of genes • Function research of reproductive system
B-Prrx1-iCre Mice 110130 Prrx1 promoter-driven Cre mouse model (mesenchyme)
B-ROSA26-EGFP-DTA mice 110156 • Function research of genes • Deletion of specific groups of cells
B-Rank-iCre mice 110133 C57BL/6
B-Sp7-iCre mice 110131 Sp7 promoter-driven Cre mouse model (skeleton)
B-Tagln-iCre mice 110146
  • Function research of genes
  • Function research of smooth muscle cell
B-Tcf21-iCreERT2 mice 110141 Tcf21 promoter-driven inducible Cre mouse model (bladder, lung)
B-Tie2-iCreERT2-EGFP mice 110781 C57BL/6
B-Ucp1-iCre Mice 110134 UCP1 promoter-driven Cre mouse model (mitochondria, brown fat)

Cre Rat Models List

Product Product No Application Fields
B-CAG-iCre rats 211350 Cre ubiquitous expression in rats
B-Drd2-Cre Rats 210488
  • Function research of genes
  • This Drd2Cre model is an efficient tool to study various gene functions when crossed with rats with different loxP site-flanked genes of interest, especially in studies of D2 dopamine receptor subtype-expressing neurons, and may be useful for studying dopamine-sensitive behaviors such as addiction.
B-Oxt-iCre rats 210501 Oxt promoter-driven Cre rat model (hypothalamus;)
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