Cre Mouse/Rat Models

Researchers use gene-edited mouse models to study gene expression, investigate genetic diseases, conduct preclinical drug efficacy tests and more. In many studies, a mouse model expresses a gene mutation throughout its development and life, necessitating an inducible disease model when researchers need more control over the mouse’s gene expression.

Mouse models that provide this level of control are called conditional mouse models, of which one of the most effective is the Cre/Loxp mouse. Cre mice lines express Cre recombinase under the control of certain tissue specific gene promoter, i.e. Cre mouse line provides the tissue specificity of gene editing. If CreERT2 instead of Cre is used, then the DNA recombinase activity is induced by Tamoxifen, so that the Cre/Loxp mouse model will be conditional and inducible. The LoxP mouse line has two loxP elements flanking the entire or part of the gene of interest, giving the loxP mouse defined gene(s) to be edited.

The Cre-Lox system is an efficient method for producing conditional mouse models. At Biocytogen, we provide custom Cre-Lox mouse models for use in academic and pharmaceutical research. We can design a Cre mouse model, conduct research and deliver results in as little as nine months. Fill out a form or contact us today to learn more.

Cre Mouse Models List

Product Product No Application Fields
B-CAG-tdTomato cKI mice 110148 Cre-induced tdTomato expression for Cre expression profile detection
B-Gfap-iCre mice 110144 Gfappromoter-driven Cre mouse model. (Astroglia)
B-Grpr-iCre Mice 110125 Grpr promoter-driven Cre mouse model (digestive system, nervous system)
B-Nkp46-iCre mice 110127 Ncr1 promoter-driven Cre mouse model (NK cell)
B-Pdgfrb-iCre Mice 110129 Pdgfrb promoter-driven inducible Cre mouse model (parietal cell of multiple organs, such as skin, intestinal tract, kidney, lung and plexus vasculosus around central nervous system)
B-Prrx1-iCre Mice 110130 Prrx1 promoter-driven Cre mouse model (mesenchyme)
B-Sp7-iCre mice 110131 Sp7 promoter-driven Cre mouse model (skeleton)
B-Tcf21-iCreERT2 mice 110141 Tcf21 promoter-driven inducible Cre mouse model (bladder, lung)
B-Ucp1-iCre Mice 110134 UCP1 promoter-driven Cre mouse model (mitochondria, brown fat)

Cre Rat Models List

Product Product No Application Fields
B-Drd2-Cre Rats 210488 Drd2 promoter-driven Cre rat model (nucleus accumbens, dorsal striatum, pituitary)
B-Oxt-iCre rats 210501 Oxt promoter-driven Cre rat model (hypothalamus;)
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