Product Cre Mouse/Rat Models

Researchers use gene-edited mouse models to study gene expression, investigate genetic diseases, conduct preclinical drug efficacy tests and more. In many studies, a mouse model expresses a gene mutation throughout its development and life. In some studies, however, researchers need more control over the mouse’s gene expression.

When conducting a study using mouse models, you may need to limit the altered genotype’s presence to a specific tissue or ensure it’s activated only at a certain point in the mouse’s lifespan. Mouse models that provide this level of control are called conditional mouse models. One of the most effective ways to create a conditional mouse model is through the Cre-Lox system. Cre mouse line expresses Cre recombinase under the control of certain tissue specific gene promoter, i.e. Cre mouse line provides the tissue specificity of gene editing. If CreERT2 instead of Cre is used, then the DNA recombinase activity is induced by Tamoxifen, so that the Cre-Lox model will be conditional and inducible. LoxP mouse line has two loxP elements flanking the whole or part of the gene so that loxP mouse defines the gene(s) to be edited.

The Cre-Lox system is an efficient method for producing conditional mouse models. At Biocytogen, we provide custom Cre-Lox mouse models for use in academic and pharmaceutical research. We can design a mouse model, conduct research and deliver results in as little as nine months. Fill out a form or contact us today to learn more.

Cre Mouse Models List

Product Product No Application Fields
B-ALB-CreERT2 Mice B-CM-014 Alb promoter-driven inducible Cre mouse model (liver)
B-CAG-tdTomato cKI Mice B-CM-066 Cre-induced tdTomato expression for Cre expression profile detection
B-CD150-iCreERT2 Mice B-CM-175 CD150 promoter-driven inducible Cre mouse model (Thymic, T cells and macrophages)
B-Col10a1-iCre Mice B-EM-001 Col10a1 promoter-driven Cre mouse model (mature hypertrophic chondrocyte)
B-Col2a1-iCre Mice B-EM-002 Col2 promoter-driven Cre mouse model (type II collencyte)
B-Dmp1-iCre Mice B-EM-003 Dmp1 promoter-driven Cre mouse model (skeleton)
B-Grpr-iCre Mice B-EM-004 Grpr promoter-driven Cre mouse model (digestive system, nervous system)
B-Ins1-iCreERT2 Mice B-EM-005 Ins1 promoter-driven inducible Cre mouse model (pancreas isletbeta cell)
B-Ncr1 (Nkp46)-iCre Mice B-EM-006 Ncr1 promoter-driven Cre mouse model (NK cell)
B-Oxr1-iCreERT2 Mice B-CM-003 Oxr1 promoter-driven inducible Cre mouse model (frontal lobe adult, cerebellum adult and 24 other tissues)
B-Pdgfrb-iCre Mice B-CM-004 Pdgfrb promoter-driven inducible Cre mouse model (parietal cell of multiple organs, such as skin, intestinal tract, kidney, lung and plexus vasculosus around central nervous system)
B-Prrx1-iCre Mice B-EM-007 Prrx1 promoter-driven Cre mouse model (mesenchyme)
B-Sp7 (Osx)-iCre Mice B-EM-008 Sp7 promoter-driven Cre mouse model (skeleton)
B-Syn1-iCre Mice B-CM-005 Syn1promoter-driven inducible Cre mouse model (brain)
B-Tnfrsf11a (RANK)-iCre Mice B-EM-009 Tnfrsf11a promoter-driven Cre mouse model (lymph gland formation and osteoclast differentiation system)
B-Ucp1-iCre Mice B-EM-010 UCP1 promoter-driven Cre mouse model (mitochondria, brown fat)
B-Zeb1-iCreERT2 Mice B-EM-011 Zeb1 promoter-driven inducible Cre mouse model (tunica media of artery and myocardial cell)

Cre Rat Models List

Product Product No Application Fields
B-3XGFP cKI Rats B-CR-017 Cre-induced GFP expression, for Cre expression profile detection
B-ALB-CreERT2 Rats B-CR-019 Alb promoter-driven inducible Cre rat model (Liver)
B-Camk2a-Cre Rats B-CR-001 Camk2a promoter-driven Cre rat model (Cortex, frontal lobe)
B-Drd1-Cre Rats B-CR-002 Drd1 promoter-driven Cre rat model (nucleus accumbens, dorsal striatum)
B-Drd2-Cre Rats B-CR-003 Drd2 promoter-driven Cre rat model (nucleus accumbens, dorsal striatum, pituitary)
B-Kit-CreERT2 Rats B-CR-004 Kit promoter-driven inducible Cre rat model (lung, cerebellum)
B-Myh6-CreERT2 Rats B-CR-018 Myh6 promoter-driven inducible Cre rat model (Heart)
B-Nphs2 (podocin)-CreERT2 Rats B-CR-005 Nphs2 promoter-driven inducible Cre rat model (Kidney)
B-Slc6a2-Cre Rats B-CR-007 Slc6a2 promoter-driven Cre rat model (Noradrenergic neuron)
B-Slc6a3 (Dat1)-Cre Rats B-CR-008 Slc6a3 promoter-driven Cre rat model (Dopaminergic neurons)
B-Sncg (Synuclein,Gamma)-Cre Rats B-CR-009 Sncg promoter-driven Cre rat model (dorsal striatum)
B-Tdtomato cKI Rats B-CR-011 Cre-induced GFP expression, for Cre expression profile detection
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