Festival of Biologics USA 2022
Speaker: Li Hui M.D., Ph.D., Director, Antibody Discovery & RenMice Licensing, Biocytogen Boston Corp
Time: 5:10pm PST, March 9th
Talk title: Streamlining Therapeutic Antibody Discovery For All Targets
- Human antibodies generated from fully human antibody transgenic mice have a higher chance of clinical success due to the in vivo natural selection and affinity maturation of antibody-secreting B cells.
- We have generated multiple strains of fully human antibody transgenic mice, including strains harboring a common light chain to streamline bispecific antibody discovery, and a strain expressing human HLA to facilitate discovery of antibodies that recognize HLA/peptide complexes.
- Using optimized immunization methods and high-throughput screening, our antibody discovery platform generates fully human antibodies with cross-species reactivity to streamline the downstream validation process.
Poster Session: James Jin, Ph.D., VP, Biocytogen Boston
Poster title: Discovery of Therapeutic Antibodies using Knockout RenMice™ Expressing Human Immunoglobulin Variable Domain Genes
The Festival of Biologics brings together pharma & biotech, academics and research institutes, together with their partners across the value chain. Across antibodies, immunotherapy and biosimilars our participants share research, create new partnerships, and tackle the clinical trials, manufacturing and commercial challenges involved in bringing new therapies to market.