Introduction to Autoimmune & Inflammation Diseases
Autoimmune diseases and other inflammatory disorders are mediated by dysfunction of the body’s immune system, typically in the form of hypersensitivity. These disorders are subject to intensive research and drug development efforts, especially inflammation models in mice. Biocytogen provides robust mouse models of inflammation, such as those of experimental autoimmune encephalomyelitis (EAE), psoriasis, and asthma. As a differentiating factor from other models on wild type animals, Biocytogen generates genetically humanized mouse models that allow researchers to interrogate the efficacy of therapeutics against specific human targets in mice critical to the underlying molecular mechanisms of autoimmune and immune-mediated inflammation diseases.
Chronic MOG-induced EAE model in human IL-17A knock-in mice (B-hIL17A) expressing human IL-17ALearn More
Ovalbumin-induced asthma model in double human IL-4 and IL-4RA knock-in mice (B-hIL4&hIL4RA) expressing both human IL-4 and human IL-4RALearn More