Basic Information
Strain name
C57BL/6-Cd200tm1(CD200)/Bcgen
Common name
B-hCD200 mice
Background
C57BL/6
Catalog number
111133
Aliases
CD200, MOX1, MOX2, MRC, OX-2, CD200 molecule
NCBI Gene ID
-
Targeting strategy
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Gene targeting strategy for B-hCD200 mice.
The exons 1-5 of mouse Cd200 gene that encode the full-length protein were replaced by human CD200 exons 1-7 in B-hCD200 mice.
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Protein expression analysis
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Strain specific CD200 expression analysis in heterozygous B-hCD200 mice by flow cytometry.
Splenocytes were collected from wild type (WT) mice (+/+) and heterozygous B-hCD200 mice (H/+), and analyzed by flow cytometry with species-specific anti-CD200 antibody. Mouse CD200 was detectable in WT mice (+/+) and heterozygous B-hCD200 mice (H/+). Human CD200 was exclusively detectable in heterozygous B-hCD200 mice (H/+) but not in WT mice (+/+).
