A Novel B2m-deficient Immunodeficient Model Expressing Human IL15 for Preclinical Evaluation of T Cell and NK Cell-based Therapies

CONCLUSION

We have generated B-NDG B2m plus/hIL15 mice, a highly immunodeficient mouse model lacking MHC I and expressing IL-15 for improved NK cell engraftment.
B-NDG B2m plus/hIL15 mice have a significantly extended life span, with reduced GvHD upon human PBMC engraftment when compared to B-NDG mice with intact MHC I.
Human CD3+ cells and CD56+ cells can be reconstituted successfully from PBMCs in B-NDG B2m plus/hIL15 mice, indicating that B-NDG B2m plus/hIL15 mice are a suitable mouse model for testing novel immunotherapies in the context of human T cell and NK cells.

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