A Novel B2m-deficient Immunodeficient Model Expressing Human IL15 for Preclinical Evaluation of T Cell and NK Cell-based Therapies

CONCLUSION

We have generated B-NDG B2m plus/hIL15 mice, a highly immunodeficient mouse model lacking MHC I and expressing IL-15 for improved NK cell engraftment.
B-NDG B2m plus/hIL15 mice have a significantly extended life span, with reduced GvHD upon human PBMC engraftment when compared to B-NDG mice with intact MHC I.
Human CD3+ cells and CD56+ cells can be reconstituted successfully from PBMCs in B-NDG B2m plus/hIL15 mice, indicating that B-NDG B2m plus/hIL15 mice are a suitable mouse model for testing novel immunotherapies in the context of human T cell and NK cells.

Please fill out the form below to request a download of this poster

First Name *

Last Name *

Company/ Institution*

Work Email *

Country *

State/ Province *

How did you hear about us? *