AACR 2020: In vivo drug screening platform accelerates anti-hCD40 antibody drug discovery
The CD40 (also known as TNFRSF5) and its ligand CD40L (also known as CD154) belong to the TNF/TNFR family. CD40 is expressed on antigen presenting…
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AACR 2020: Novel TNFR2 humanized mouse model for human TNFR2 antibody evaluation
In recent years, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily…
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AACR 2020: Evaluating anti-IL-2Ra in vivo efficacy on humanized knock-in mice
Interleukin-2 receptor alpha chain (also called as CD25) is a 55 kD glycoprotein, also known as IL-2Ra, Ly-43, p55, or Tac. It is expressed on activated…
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AACR 2020: Rapid screening of novel OX40 agonistic antibodies for cancer immunotherapy
OX40, also known as TNFRSF4 or CD134, is a member of the tumor necrosis factor receptor superfamily and is an important co-stimulator of T cell…
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AACR 2020: A novel anti-CTLA-4 antibody with potent anti-tumor activity emerged using humanized CTLA-4 mouse model
CTLA-4 (Cytotoxic T-lymphocyte antigen 4), also known as CD152, belongs to immunoglobulin superfamily. It is an intracellular protein expressed in resting T cells; CTLA-4 translocates…
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AACR 2020: Long-term Maintenance of Human Mature NK Cells from hCD34+HSCs Engraftment Supported by Immune Humanized B-NDG hIL15 Mice
Human HSC (hematopoietic stem cells) engrafted humanized mice are a powerful model that allows researchers to examine the human immune system and evaluate cellular immunotherapy…
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AACR 2020: Development of a novel engineered B2M mouse strain on B-NDG background that specifically eliminates MHC I expression while retaining normal FcRn-mediated antibody retention
Severely immunodeficient mouse strains, such as NOD.Cg-Prkdcscid Il2rg-/- , have been widely used to evaluate human immune responses, including applications in immuno-oncology in recent years.…
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AACR 2020: Evaluating anti-PD-1/4-1BB combination therapy: In vivo efficacy with humanized double knock-in mice
The transmembrane protein receptor 4-1BB is a member of the tumor necrosis factor (TNF) receptor super family and is involved in the co-stimulation of immune…
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AACR 2020: Immune biomarker profiling and safety evaluation response to 4-1BB antibody (Urelumab) in humanized 4-1BB mice
4-1BB (CD137) belongs to the TNFR superfamily and is expressed by activated CD4 helper T cells, B cells, natural killer cells, natural killer T cells,…
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AACR 2020: Optimization of novel anti-4-1BB antibodies on Biocytogen’s in vivo drug screening platform
4-1BB (CD137, tumor necrosis factor receptor superfamily 9) is an inducible costimulatory receptor expressed on activated T and natural killer (NK) cells. 4-1BB ligation on…
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Novel IL4/IL4RA double humanized mouse models for in vivo efficacy evaluation of human IL4 and human IL4RA antibodies in asthma models
Pleiotropic cytokines (interleukin(IL)-4/13) and their pertinent receptors (such as IL-4 receptor) are promising therapeutic targets due to their pivotal roles in the physiopathology of…
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AACR 2020: RenMab Mouse – A leading platform for fully human antibody generation
With the development of immune-oncology, therapeutic antibodies have been proven to be extraordinarily effective for cancer treatment. Conventional human antibody discovery process can be divided…
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