Efficacy and toxicity evaluation of anti-human CD47 and SIRPa antibodies in genetically humanized B-hSIRPa/hCD47 mice
CD47 is a transmembrane protein expressed ubiquitously on the surface of human cells, including. SIRPa, one of the binding partners of CD47, is a member…
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Novel humanized CD3ε mouse model for evaluation of bi-specific T-cell engager antibodies
CD3ε is one of the key signaling subunits of the CD3 co-receptor of the T cell receptor (TCR) complex. This TCR complex plays critical role…
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Rapid Therapeutic Antibody Development Using Fully Human Antibody Mouse
Therapeutic antibodies have been proven to be remarkably effective for immunotherapies. Most human antibodies were discovered through conventional antibody discovery process, which can be divided…
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The Human Immune System Reconstituted B-NDG Mouse Models are Perfect Tools for CAR-T and Therapeutic Antibody Preclinical Efficacy Evaluation
The B-NDG mice (NOD-Prkdcscid Il2rgtm1/Bcgen) were independently developed by Biocytogen to knockout IL2rg gene in NOD-SCID mouse background. Here we demonstrated that B-NDG, as one of…
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Anti-SIRPα Antibodies as A Potential Weapon for Cancer Immunotherapy via Accelerated Screening in Humanized Mouse Models
Signal regulatory protein α (SIRPα) is a transmembrane protein and is especially abundant in myeloid cells such as macrophages and DCs, whereas it is expressed…
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Novel hCD3e Mouse Models for Preclinical Pharmacology Study of Therapeutic Bispecific Antibody
CD3e is one of four subunits of the CD3 co-receptor, which plays an important role in the immune response, associating with the T cell receptor…
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Rapid Screening of Anti-OX40 Antibodies for Cancer Immunotherapy
OX40 is a co-stimulatory receptor, and it interacts with its ligand to provide positive signal for T cell activation. Disruption of the OX40 pathway led…
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Biocytogen’s In Vivo Drug Screening Platform Accelerated 4-1BB Agonistic Antibody Development
4-1BB (TNFRSF9/CD137) belongs to the TNFR superfamily. 4-1BB is expressed by activated CD4 helper T cells, B cells, natural killer cells, natural killer T cells,…
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Evaluating Anti-PD-1/CD40 In Vivo Efficacy and Safety on Humanized Double Knock-in Mice
Over the past years, monoclonal antibodies have been successfully utilized in clinical trials to block or active key mediators of immune checkpoint pathways. However, along…
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Novel CTLA-4 Antibodies of Potent Antitumor Activity Were Verified in Humanized Mouse Models
CTLA-4 is a member of the immunoglobulin superfamily, and is homologous to the co-stimulatory protein CD28, and both receptors bind to the same ligands, CD80(B7-1)…
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Novel anti-CD40 Antibodies Demonstrate Anti-tumor Activity in Humanized Mouse Models
CD40, Cluster of Differentiation 40, is a member of the TNF-receptor superfamily. Whereas most immune checkpoint receptors are expressed on the surface of T cells,…
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PK-PD Modelling of An Anti-CTLA-4 Antibody on Immune Checkpoint Humanized Mice
Cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4; also known as CD152) is expressed on the surface of T cells, where it primarily suppresses their early stages of…
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