The Human Immune System Reconstituted B-NDG Mouse Models are Perfect Tools for CAR-T and Therapeutic Antibody Preclinical Efficacy Evaluation
The B-NDG mice (NOD-Prkdcscid Il2rgtm1/Bcgen) were independently developed by Biocytogen to knockout IL2rg gene in NOD-SCID mouse background. Here we demonstrated that B-NDG, as one of…
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Anti-SIRPα Antibodies as A Potential Weapon for Cancer Immunotherapy via Accelerated Screening in Humanized Mouse Models
Signal regulatory protein α (SIRPα) is a transmembrane protein and is especially abundant in myeloid cells such as macrophages and DCs, whereas it is expressed…
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Novel hCD3e Mouse Models for Preclinical Pharmacology Study of Therapeutic Bispecific Antibody
CD3e is one of four subunits of the CD3 co-receptor, which plays an important role in the immune response, associating with the T cell receptor…
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Rapid Screening of Anti-OX40 Antibodies for Cancer Immunotherapy
OX40 is a co-stimulatory receptor, and it interacts with its ligand to provide positive signal for T cell activation. Disruption of the OX40 pathway led…
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Biocytogen’s In Vivo Drug Screening Platform Accelerated 4-1BB Agonistic Antibody Development
4-1BB (TNFRSF9/CD137) belongs to the TNFR superfamily. 4-1BB is expressed by activated CD4 helper T cells, B cells, natural killer cells, natural killer T cells,…
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Evaluating Anti-PD-1/CD40 In Vivo Efficacy and Safety on Humanized Double Knock-in Mice
Over the past years, monoclonal antibodies have been successfully utilized in clinical trials to block or active key mediators of immune checkpoint pathways. However, along…
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Novel CTLA-4 Antibodies of Potent Antitumor Activity Were Verified in Humanized Mouse Models
CTLA-4 is a member of the immunoglobulin superfamily, and is homologous to the co-stimulatory protein CD28, and both receptors bind to the same ligands, CD80(B7-1)…
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Novel anti-CD40 Antibodies Demonstrate Anti-tumor Activity in Humanized Mouse Models
CD40, Cluster of Differentiation 40, is a member of the TNF-receptor superfamily. Whereas most immune checkpoint receptors are expressed on the surface of T cells,…
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PK-PD Modelling of An Anti-CTLA-4 Antibody on Immune Checkpoint Humanized Mice
Cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4; also known as CD152) is expressed on the surface of T cells, where it primarily suppresses their early stages of…
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Using Humanized B-hSIRPa/hCD47 Mouse Model to Evaluate the Efficacy and Toxicity of CD47 and SIRPa Antibodies
CD47 is a transmembrane protein expressed the surface of many cells in the body. SIRPa, which is expressed on phagocytic cells, was identified as the…
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Biocytogen’s In Vivo Drug Screening Platform Accelerated 4-1BB Agonistic Antibody Development
4-1BB (TNFRSF9/CD137) belongs to the TNFR superfamily. 4-1BB is expressed by activated CD4 helper T cells, B cells, natural killer cells, natural killer T cells,…
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