AACR 2021: Humanized B-hC5AR1 mouse model for evaluation of anti-C5AR1 mAb in vivo efficacy

AACR 2021: Humanized B-hC5AR1 mouse model for evaluation of anti-C5AR1 mAb in vivo efficacy

Author: Yanhui Niu, Xiaofei Zhou, Jing Zhang, Veronika Chromikova, Yuelei Shen

  • Activated myeloid-derived suppressor cells upregulate C5AR1 expression, which plays a significant role in inhibiting T cell-related responses. 
  • Increased cancer cell invasion and growth by the C5a-C5AR1 system presents an attractive target for cancer therapy. 
  • Biocytogen generated a humanized B-hC5AR1 mouse model by replacing the murine C5ar1 gene with the human ortholog by homologous recombination. 
  • Homozygous B-hC5AR1 mice do not exhibit changes in the overall development, differentiation or distribution of T cells, B cells, NK cells, dendritic cells, granulocytes, monocytes, macrophages, CD8+ T cells, CD4+ T cells, and Tregs.  

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