AACR 2021: SIGLEC15 humanized knock-in mice are a powerful tool to evaluate new therapies for cancer and osteoporosis

AACR 2021: SIGLEC15 humanized knock-in mice are a powerful tool to evaluate new therapies for cancer and osteoporosis

Author: Huilin Li, Lei Zhao, Maopeng Tian, Veronika Chromikova, Zhaoxue (Luke) Yu


  • Non-redundant to PD-L1, SIGLEC15 interacts with CD8 T cells, which results in suppression of anti-tumor immune responses.
  • Biocytogen has generated a humanized B-hSIGLEC15 mouse model, and a human SIGLEC15-expressing MC38 cell line (hSIGLEC15-MC38) to address the need for both in vitro functional validation and in vivo efficacy evaluation of SIGLEC15 drug candidates. 
  • Homozygous B-hSIGLEC15 mice do not exhibit a change in the overall development, differentiation or distribution of leukocyte subpopulations isolated from spleen, lymph nodes, and blood. 
  • Anti-human SIGLEC15 antibodies showed modest tumor inhibition in B-hSIGLEC15 mice inoculated with hSIGLEC15-MC38 tumor cells. 
  • B-hSIGLEC15 mice can be used for in vivo efficacy evaluation of anti-human SIGLEC15 antibodies in immune normalization approaches for cancer treatment. 

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