AACR 2021: TNFR2 and PD-1/PD-L1/TNFR2 humanized mice aid exploration of combination strategies to overcome tumor immune escape mechanisms

AACR 2021: TNFR2 and PD-1/PD-L1/TNFR2 humanized mice aid exploration of combination strategies to overcome tumor immune escape mechanisms

Author: Huilin Li, Xiaofei Zhou, Jing Zhang, Veronika Chromikova, Qingcong Lin

  • TNF signaling via TNFR2 plays an important role in modulation of the immune system via pro- and anti-inflammatory activities of T cells. 
  • Biocytogen has generated a humanized B-hTNFR2 and a humanized B-hPD-1/hPD-L1/hTNFR2 mouse model to evaluate in vivo efficacy of TNFR2 antibodies.
  •  Anti-human TNFR2 antibodies inhibited MC38 tumor growth in B-hTNFR2 mice.
  • B-hTNFR2 and B-hPD-1/hPD-L1/hTNFR2 mice are useful models to explore anti-PD-1, anti-PD-L1, and anti-TNFR2 combination therapy strategies, with promising activity and low cytotoxicity. 

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