AACR 2022: Generation of TCR-like fully human antibodies against HLA-antigen-peptide complexes using HLA transgenic RenMice

AACR 2022: Generation of TCR-like fully human antibodies against HLA-antigen-peptide complexes using HLA transgenic RenMice

Conclusions

  • We describe an HLA transgenic mouse that acquires fully human TCR mimic antibodies through a proprietary immunization procedure.
  • Beacon on-chips screening and high-throughput binding validation accelerate antibody discovery.
  • Diversified antibody sequences ensure the screening of antibodies with high specificity and high affinity.

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