Events

View All

    AACR 2023: D02, A Novel, Non-Blocking Antibody Targeting IL2RA, Exhibits Significant Anti-Tumor Activity in IL2RA-Humanized Mice

    April 17, 2023
    Share on:
    D02 is a fully human IgG1 antibody specific to IL2RA that was obtained from RenMabTM humanized immunoglobulin mice. D02 binds both human and cynomolgus monkey IL2RA with high affinity. D02 binds to the sushi2 epitope of IL2RA without obstructing the binding of IL-2 or inhibiting IL-2 signaling. D02 exhibits anti-tumor efficacy when administered to mice harboring MC38 tumors.