SITC 2023: BCG022: A HER3×MET Bispecific Antibody-drug Conjugate (BsADC) Targeting Key Mechanisms of Bypass Resistance in Multiple Tumor Types

SUMMARY

HER3 and MET were co-expressed in various tumor types, and their signaling plays a key role in EGFR TKI drug resistance.
HER3×MET bsAbs generated from the RenLite® platform contain a full human heavy chain variable domain with a common human kappa light chain, demonstrating cross-species reactivity to human and cynomolgus monkey antigens.
HER3×MET bsAbs bound to a variety of HER3/MET co-expressing tumor lines, including NSCLC, gastric, liver, and colorectal cancers, and have enhanced internalization activity in the NUGC-4 cell line.
Both BCG022-vcMMAE and BCG022-BLD1102 bsADCs showed superior or comparable anti-tumor activity to the benchmark ADCs in CDX and PDX models.

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