AET2023: Discovery of RenNano®-derived human heavy-chain-only TFR1 antibodies that can efficiently cross the blood-brain barrier and deliver drug payload

AET2023: Discovery of RenNano®-derived human heavy-chain-only TFR1 antibodies that can efficiently cross the blood-brain barrier and deliver drug payload

Summary 

• hTFR1-targeting HCAbs developed from RenNano® mice have nM range affinity to human TFR1, and have functional capabilities, including internalization capacity.
• hTFR1-targeting HCAbs are able to penetrate the BBB and deliver drug payload to the brain parenchyma efficiently.
• Together, these data highlight the tremendous potential for HCAbs and its variable domain sdAbs for transporting cargo across the BBB. Due to their smaller size and simpler structure, sdAbs could ultimately provide therapeutic benefit for neurodegenerative diseases, and offer promising potential for tumor penetration.

 

Share:

    Please fill out the form below to request a download of this poster

    WordPress Double Opt-in by Forge12