AACR 2024: TIL analysis demonstrates different mechanisms underlying PD-1 resistance in animal models

AACR 2024: TIL analysis demonstrates different mechanisms underlying PD-1 resistance in animal models

Used in the poster: B-hPD-1/hPD-L1 mice

Summary:

Resistance to PD-1 immunotherapy presents a significant challenge in cancer treatment, often associated with alterations in the tumor microenvironment and tumor-infiltrating lymphocytes (TILs) after treatment. Immune cell profiling in various tumor models revealed variations in TIL frequencies, with changes observed during cancer progression. Investigation of PD-1 resistant models, induced by hPD-1 antibody retreatment and observed in aged mice, demonstrated distinct mechanisms of resistance, including alterations in TIL composition and increased inhibitory myeloid-derived suppressor cell (MDSC) populations. These findings underscore the importance of TIL analysis in predicting responsiveness to PD-1 therapy and guiding treatment approaches.

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