Basic Information

Strain Name
NOD.CB17-PrkdcscidBcgenIL2rgtm1BcgenH2-K1tm1BcgenH2-D1tm1Bcgen/Bcgen
Common Name
B-NDG H2-K1/H2-D1 KO mice
Background
B-NDG
Catalog Number
112256
NCBI Gene ID
Related Genes
H2-K1: H-2K, H-2K(d), H2-D1, H2-K, K-fH2-D1: H-2D, H2-D, H2-K1

Targeting strategy

Gene targeting strategy for B-NDG H2-K1/H2-D1 KO mice. The exons 2-8 of mouse H2-K1 and H2-D1 genes were knocked out in B-NDG H2-K1/H2-D1 KO mice.

Protein expression analysis

Strain specific H2-Kb/H2-Db (α chain of MHC-I molecule) expression analysis in B-NDG mice and B-NDG H2-K1/H2-D1 KO mice by flow cytometry. Bone marrow, spleen and blood were collected from B-NDG mice and B-NDG H2-K1/H2-D1 KO mice, and analyzed by flow cytometry. Mouse H-2Kb/H-2Db was only detectable in B-NDG mice but not in B-NDG H2-K1/H2-D1 KO mice.

Summary

Protein expression analysis:
Mouse H-2Kb/H-2Db was only detectable in B-NDG mice but not in B-NDG H2-K1/H2-D1 KO mice.

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