Basic Information
Strain Name
NOD.CB17-PrkdcscidIl2rgtm1Il6tm1(IL6)/Bcgen
Common Name
huHSC-B-NDG hIL6 mice
Background
B-NDG
Catalog Number
112864
NCBI Gene ID
Related Genes
BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6
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Human CD34+ HSCs immune system engraftment
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B-NDG hIL6 mice are well suited for human monocytes reconstitution. Human CD34+ HSCs (0.15 M) were intravenous implanted into homozygous B-NDG hIL6 and B-NDG mice (female, 6 week-old, n=15). All mice were treated with 1.6 Gy-irradiation. Flow cytometry analysis were performed with PBMCs from mice engrafted with human CD34+ HSCs. B-NDG hIL6 mice show higher percentages of human myeloid cells and monocytes compared with B-NDG mice.
