Basic Information

Strain Name
NOD.CB17-PrkdcscidBcgenIl2rgtm1BcgenB2mtm2(B2M/HLA-A2.1)Bcgen/Bcgen
Common Name
huHSC-B-NDG HLA-A2.1 mice
Background
B-NDG
Catalog Number
112865
NCBI Gene ID
Related Genes
B2m: Ly-m11, beta2-m, beta2mHLA-A: HLAA

Human CD34+ HSCs engraftment

B-NDG HLA-A2.1 mice

Human CD34+ HSCs were successfully engrafted in B-NDG HLA-A2.1 mice. Human CD34+ HSCs were respectively engrafted in new born mice of B-NDG HLA-A2.1 mice and B-NDG mice after radiated with 0.8 Gy. (A) B-NDG HLA-A2.1 mice showed slightly lower survival rate than B-NDG mice, but no statistically significant difference. (B) Body weight.

B-NDG MGMT3 mice

Human CD34+ HSCs were successfully engrafted in B-NDG HLA-A2.1 mice. Human CD34+ HSCs were respectively engrafted in new born mice of B-NDG HLA-A2.1 mice and B-NDG mice after radiated with 0.8 Gy. Human leukocytes were analyzed by flow cytometry. Results showed that although the proportion of hCD8 + T cells in B-NDG HLA-A2.1 mice was significantly lower than that in B-NDG mice, it remains sustained at around 18% within 24 weeks of reconstitution. The proportion of hCD4 + T cells in B-NDG HLA-A2.1 mice was significantly higher than that in B-NDG mice. Proportions of other reconstituted cell types in B-NDG HLA-A2.1 mice were similar to that in B-NDG mice.

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