Basic Information

Strain Name
C57BL/6-Cdh5tm1(iCre/ERT2)Bcgen/Bcgen
Stock Number
110140
Common Name
B-Cdh5-iCreERT2 mice
Gene symbol and name
Cdh5, Cadherin-5
Background
C57BL/6N
Chromosome
8
Coat color
Black
Dietary information
Growth and reproduction diet for experimental mice
Expressed gene

ICreERT2, improved cre recombinase, bacteriophage P1 fused estrogen receptor

Site of expression
The endothelial cells in mice
Application
•Function research of genes •Research on cardiovascular system, tumor and cell differentiation mechanism

Description

Homozygous generally embryonic lethal, behave abnormal blood vessel development. In this strain, iCre-ERT2 recombinase expression is under the control of Cdh5 promoter. An iCre-ERT2 sequence cassette was placed between the coding sequence of exon 2 and 5’UTR of the Cdh5 gene, and the expression of endogenous Cdh5 gene in mice was disrupted. When crossed with a strain containing a loxP-site flanked sequence of interest, and induced with Tamoxifen, Cre-mediated recombination will result in deletion of the floxed sequence in the offspring.

Phenotype analysis

Immunofluorescent images of tdTomato and CD31 in the main organs of double-positive mice. CD31 is endothelial marker. Scale bar, 25 µm.

Publication

Endothelial TET2 regulates the white adipose browning and metabolism via fatty acid oxidation in obesity

The ATF4-RPS19BP1 axis modulates ribosome biogenesis to promote erythropoiesis

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