Basic Information
Strain Name
SD-Ldlrtm1/Bcgen
Stock Number
210506
Common Name
B-Ldlr KO rats
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Ldlr (low density lipoprotein receptor)
FH, FHC, FHCL1, LDLCQ2
Background
Sprague Dawley
Appearance
White
Genotypes
LdlrKO (mut/mut)
Application
Diabetes and obesity research, cardiovascular research & metabolism research etc.
NCBI Gene ID
Description
The Low Density Lipoprotein (LDL) Receptor is a cell-surface receptor presented in clathrin-coated pits that mediates the endocytosis of LDL, the major cholesterol-carrying lipoprotein of plasma. Loss of Ldlr function leads to accumulation of excess LDL in the blood, leading to elevated serum cholesterol, especially when fed a high fat diet, which makes Ldlr knockout rat a good model for studying atherosclerosis, familial hypercholesterolemia. This rat can be used to support research in many areas including diabetes and obesity research, cardiovascular research, metabolism research etc.
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Targeting Strategy
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Model validation
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Homozygous Ldlrtm1/Bcgen rats demonstrate significantly elevated serum cholesterol levels at 4 months of age.
