Basic Information

Strain Name
SD-Rag2tm1/Bcgen
Common Name
B-Rag2 KO rats
Background
SD
Catalog number
210511
Aliases
RAG-2
NCBI Gene ID

Description

The recombinant-activating gene 2 (Rag2) plays an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the initiation of V(D)J recombination. Loss of Rag2 protein leads to no mature T and B cells, the critical components of the adaptive immune system. This rat can be used to support research in many areas including immune system defections, virology research and cancer research etc.

Targeting strategy

Model validation and analysis

Homozygous Rag2tm1/Bcgen rat showed completely loss of Rag2 full length RNA in thymus.

Homozygous Rag2tm1/Bcgen rats demonstrate significantly reduced mature T and B cells, but increased NK cells.

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