Basic Information
Strain Name
SD-Rag2tm1/Bcgen
Common Name
B-Rag2 KO rats
Background
SD
Catalog number
210511
Aliases
RAG-2
NCBI Gene ID
Description
The recombinant-activating gene 2 (Rag2) plays an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the initiation of V(D)J recombination. Loss of Rag2 protein leads to no mature T and B cells, the critical components of the adaptive immune system. This rat can be used to support research in many areas including immune system defections, virology research and cancer research etc.
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Targeting strategy
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Model validation and analysis
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Homozygous Rag2tm1/Bcgen rat showed completely loss of Rag2 full length RNA in thymus.
Homozygous Rag2tm1/Bcgen rats demonstrate significantly reduced mature T and B cells, but increased NK cells.
