Basic Information
Strain Name
C57BL/6-Tnfsf13btm1(TNFSF13B)/Bcgen
Common Name
B-hBAFF mice
Background
C57BL/6
Catalog number
110830
Aliases
TNFSF13B, BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, TNLG7A, ZTNF4, TNF superfamily member 13b
NCBI Gene ID
-
Targeting strategy
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Gene targeting strategy for B-hBAFF mice.
The exons 1-7 of mouse Tnfsf13b gene that encode the extracellular domain were replaced by human TNFSF13B exons 1-6 in B-hBAFF mice.
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Protein expression analysis
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Strain specific BAFF expression analysis in wild type (WT) mice and B-hBAFF mice by ELISA.
Serum were collected from WT mice (+/+) and heterozygous B-hBAFF mice (H/+), and analyzed by ELISA with species-specific BAFF ELISA kit. Mouse BAFF was detectable in WT mice (+/+) and heterozygous B-hBAFF mice (H/+). Human BAFF was exclusively detectable in heterozygous B-hBAFF mice (H/+). ND: not detectable.
