Basic Information

Strain name
C57BL/6-Pcsk9tm1(PCSK9)/Bcgen
Common name
B-hPCSK9 mice
Background
C57BL/6
Catalog number
110928
NCBI Gene ID
Related genes
proprotein convertase subtilisin/kexin type 9, FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9

Targeting strategy

The exons 1-12 of mouse Pcsk9 gene that encode the full-length protein were replaced by human PCSK9 exons 1-12 in B-hPCSK9 mice.

Protein expression analysis

Strain specific PCSK9 expression analysis in heterozygous B-hPCSK9 mice by ELISA.

Serum was collected from wild-type mice (+/+) and heterozygous B-hPCSK9 mice (H/+), and analyzed by ELISA with species-specific PCSK9 ELISA kit. Mouse PCSK9 was detectable in wild-type mice and heterozygous B-hPCSK9 mice. Human PCSK9 was exclusively detectable in heterozygous B-hPCSK9 mice but not in wild-type mice. ND: not detected.