Basic Information
Strain Name
C57BL/6N-Cxcr3tm1(CXCR3)Bcgen/Bcgen
Common Name
B-hCXCR3 mice
Background
C57BL/6N
Catalog number
110969
Aliases
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
NCBI Gene ID
-
Targeting strategy
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Gene targeting strategy for B-hCXCR3 mice. The full coding region of mouse Cxcr3 was replaced by human CXCR3 coding region sequences in B-hCXCR3 mice.
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Protein expression analysis
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Strain specific CXCR3 expression analysis in homozygous B-hCXCR3 mice by FACS. Splenocytes were collected from wild type (+/+) and homozygous B-hCXCR3 mice (H/H) stimulated with anti-mCD3ε antibody in vivo, and analyzed by FACS with species-specific anti-CXCR3 antibody. Mouse CXCR3 was detectable in wild type mice. Human CXCR3 was exclusively detectable in homozygous B-hCXCR3 mice but not in wild type mice.
