Basic Information
Strain Name
C57BL/6-Bsgtm1(BSG)/Bcgen
Common Name
B-hCD147 mice
Background
C57BL/6N
Catalog number
110995
Aliases
BSG, 5F7, CD147, EMMPRIN, EMPRIN, HAb18G, OK, TCSF
NCBI Gene ID
-
Gene targeting strategy
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Gene targeting strategy for B-hCD147 mice. Exons 2-6 of the mouse Cd147 gene that encode the extracellular domain were replaced by human CD147 exons 2-6 in B-hCD147 mice.
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Protein expression analysis
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Species-specific CD147 protein expression analysis in wild-type and humanized B-hCD147 mice. Blood was collected from wild-type C57BL/6 (+/+) and heterozygous B-hCD147 (H/+) mice, and analyzed by flow cytometry using species-specific anti-CD147 antibodies. Murine CD147 protein was detected in wild-type and B-hCD147 mice, while human CD147 protein was exclusively detected in B-hCD147 mice.
