BSG, 5F7, CD147, EMMPRIN, EMPRIN, HAb18G, OK, TCSF
NCBI Gene ID
Gene targeting strategy
Gene targeting strategy for B-hCD147 mice. Exons 2-6 of the mouse Cd147 gene that encode the extracellular domain were replaced by human CD147 exons 2-6 in B-hCD147 mice.
Protein expression analysis
Species-specific CD147 protein expression analysis in wild-type and humanized B-hCD147 mice. Blood was collected from wild-type C57BL/6 (+/+) and heterozygous B-hCD147 (H/+) mice, and analyzed by flow cytometry using species-specific anti-CD147 antibodies. Murine CD147 protein was detected in wild-type and B-hCD147 mice, while human CD147 protein was exclusively detected in B-hCD147 mice.