Basic Information
Strain Name
C57BL/6-Clutm1(CLU)Bcgen/Bcgen
Common Name
B-hCLU mice
Background
C57BL/6
Catalog number
111430
Aliases
CLU (AAG4, APO-J, APOJ, CLI1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, CLU)
NCBI Gene ID
-
Targeting strategy
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Gene targeting strategy for B-hCLU mice.
The exon 2-9 of mouse Clu gene that encode the full-length protein were replaced by human CLU exon 2-9 in B-hCLU mice.
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Protein expression analysis
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Strain specific CLU expression analysis in homozygous B-hCLU mice by ELISA. Serum were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hCLU mice (H/H), and analyzed by ELISA with species-specific CLU ELISA kit. Mouse CLU was detectable in wild-type mice. Human CLU was exclusively detectable in homozygous B-hCLU but not wild-type mice.
