Basic Information

Strain Name
C57BL/6-Ctla4tm1(CTLA4)Tnfr2tm1(TNFR2)/Bcgen
Common Name
B-hCTLA4/hTNFR2 mice
Background
C57BL/6
Catalog number
111843
Aliases
CTLA4:CTLA-4; ALPS5; GRD4; CTLA4; CD; CD152; IDDM12; GSE; CELIAC3 TNFR2: p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II
NCBI Gene ID

Protein expression analysis

Species-specific CTLA4 protein expression analysis in wild-type and humanized B-hCTLA4/hTNFR2 mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and homozygous B-hCTLA4/hTNFR2 (H/H) mice and analyzed by flow cytometry using species-specific anti-CD152 (CTLA4) antibodies. Murine CTLA4 protein was detected in wild-type mice, while human CTLA4 protein was detected in B-hCTLA4/hTNFR2 mice.

Species-specific TNFR2 protein expression analysis in wild-type and humanized B-hCTLA4/hTNFR2 mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and homozygous B-hCTLA4/hTNFR2 (H/H) mice and analyzed by flow cytometry using species-specific anti-TNFR2 antibodies. Murine TNFR2 protein was detected in wild-type mice, while human TNFR2 protein was detected in B-hCTLA4/hTNFR2 mice.

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