Basic Information

Strain Name
C57BL/6-Itgb7tm1(ITGB7)/Bcgen
Common Name
B-hITGB7 mice
Background
C57BL/6
Catalog Number
111246
NCBI Gene ID
Related Gene
integrin subunit beta 7, Ly69

Targeting Strategy

Gene targeting strategy for B-hITGB7 mice.

The exons 2-14 of mouse Itgb7 gene that encode the extracellular domain were replaced by human ITGB7 exons 3-15 in B-hITGB7 mice.

Protein Expression Analysis

Species-specific ITGB7 expression analysis in humanized B-ITGB7 mice. Splenocytes were collected from wild-type C57BL/6 (+/+) and heterozygous B-hITGB7 (H/+) mice and analyzed by flow cytometry using species-specific anti-ITGB7 antibodies. Mouse ITGB7 was detected in wild-type and heterozygous B-hITGB7 mice, while human ITGB7 was exclusively detected in B-ITGB7 mice.