Basic Information

Strain name
C57BL/6-Robo4tm1(ROBO4)/Bcgen
Common name
B-hROBO4 mice
Catalog number
111022
Background
C57BL/6
Aliases
AOVD3, ECSM4, MRB(magic roundabout)
NCBI Gene ID

Targeting strategy

The exons 1-9 of mouse Robo4 gene that encode the extracellular domain were replaced by human ROBO4 exons 1-9 in B-hROBO4 mice.

Protein expression analysis

Strain specific ROBO4 expression analysis in homozygous B-hROBO4 mice by western blot. Lung tissues were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hROBO4 mice (H/H), and analyzed by western blot with anti-ROBO4 antibody. Human ROBO4 was exclusively detectable in homozygous B-hROBO4 mice.