Basic Information

Strain name
C57BL/6-Tfr1tm1TFR1/Bcgen
Common name
B-hTFR1 mice
Catalog number
110861
Background
C57BL/6
Aliases
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
NCBI Gene ID

Targeting strategy

The exons 4-19 of mouse Tfr1 gene that encode the extracellular region were replaced by human TFR1 exons 4-19 in B-hTFR1 mice.

Protein expression analysis

Strain specific TFR1 expression analysis in homozygous B-hTFR1 mice by flow cytometry.  Bone marrow was collected from wild-type C57BL/6 mice (+/+) and homozygous B-hTFR1 mice (H/H), and analyzed by flow cytometry with species-specific anti-TFR1 antibody. Mouse TFR1 was exclusively detectable in wild-type C57BL/6 mice. Human TFR1 was exclusively detectable in homozygous B-hTFR1 mice.

Poster

AACR 2022: Evaluating Delivery of TFR1-targeting Therapies to the CNS in a Novel Humanized TFR1 Mouse Model