Basic Information

Common Name:
B-hTGFBR2 mice
Catalog number
110874
Background
C57BL/6
NCBI Gene ID

Gene Targeting Strategy

The chimeric coding sequence (mouse signal peptide, human extracellular domain and mouse transmembrane and intracellular domain) was inserted to replace part of murine Tgfbr2 exon 2 B-hTGFBR2 mice.

Protein Expression Analysis

Species-specific TGFBR2 expression analysis in humanized B-hTGFBR2 mice. Splenocytes were collected from wild-type C57BL/6 (+/+) and heterozygous B-hTGFBR2 (H/+) mice and analyzed by flow cytometry using species-specific anti-TGFBR2 antibodies. Murine TGFBR2 was detected in wild-type and heterozygous B-hTGFBR2 mice, while human TGFBR2 was exclusively detected in B-hTGFBR2 mice.