Basic Information
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Targeting strategy
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Gene targeting strategy for B-nude rats. The exons 3~9 of rat Foxn1 gene were knocked out in B-nude rats.
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B-nude rats exhibit no hair and no thymus
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Phenotype analysis of B-nude rats. A. The image shows that homozygous B-nude rats are hairless. B. Gross anatomy of thymus in wild-type SD rats and B-nude rats were showed (female, 11-week-old). There was no obvious thymic tissue in B-nude rats compared to wild-type SD rats. C, D. Spleen and thymus were isolated and weighed. Spleen size and weight of B-nude rats were similar to that of wild-type SD rats. Compared to wild-type SD rats, there is little to no thymic tissue in nude rats.
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Summary
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Gross anatomy of thymus and weight of thymus and spleen:
B-nude rats are hairless and athymic. Spleen size and weight of B-nude rats were similar to that of wild-type SD rats.
