Basic Information

Strain Name
SD-Ldlrtm1Bcgen/Bcgen
Stock Number
210506
Common Name
B-Ldlr KO rats
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Ldlr (low density lipoprotein receptor) FH, FHC, FHCL1, LDLCQ2
Background
Sprague Dawley
Appearance
White
Genotypes
LdlrKO (mut/mut)
Application
Diabetes and obesity research, cardiovascular research & metabolism research etc.
NCBI Gene ID

Description

The Low Density Lipoprotein (LDL) Receptor is a cell-surface receptor presented in clathrin-coated pits that mediates the endocytosis of LDL, the major cholesterol-carrying lipoprotein of plasma. Loss of Ldlr function leads to accumulation of excess LDL in the blood, leading to elevated serum cholesterol, especially when fed a high fat diet, which makes Ldlr knockout rat a good model for studying atherosclerosis, familial hypercholesterolemia. This rat can be used to support research in many areas including diabetes and obesity research, cardiovascular research, metabolism research etc.

Targeting Strategy

Model validation

Homozygous Ldlrtm1/Bcgen rats demonstrate significantly elevated serum cholesterol levels at 4 months of age.

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