Basic Information
Strain Name
NOD.CB17-Prkdcscid Il2rgtm1Bcgen Kittm1(V831M)Bcgen/Bcgen
Common Name
B-NDG Kit W41 mice
Background
B-NDG
Catalog number
112914
Aliases
PBT, SCFR, C-Kit, CD117, MASTC
NCBI Gene ID
Application Fields
This product can accept human hematopoietic stem cell transplantation without irradiation, making it suitable for research in the fields of blood and immunity.
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mRNA expression analysis
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Strain specific analysis of Kit mRNA expression in B-NDG mice and B-NDG Kit W41 mice by RT-PCR. Spleen and lung RNA was isolated from B-NDG mice (+/+) and heterozygous B-NDG Kit W41 mice (Mut/+), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mouse Kit primers. Mouse Kit mRNA were detectable in B-NDG mice (+/+) and B-NDG Kit W41 mice (Mut/+). Sequence assays showed the B-NDG Kit W41 mice (Mut/+) consists of a G to A point mutation at amino acid 831.
